ArticleAfrican health sciences2005
Evaluation of CD4(+)/CD8(+) status and urinary tract infections associated with urinary schistosomiasis among some rural Nigerians.
Article in African health sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Effects of Schistosoma haematobium infection and treatment on the systemic and mucosal immune phenotype, gene expression and microbiome: A systematic review.PLoS neglected tropical diseases · 2024Pooled it
- Schistosomiasis: Still a Cause of Significant Morbidity and Mortality.Research and reports in tropical medicine · 2019Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundData on urinary schistosomiasis in Nigeria are mainly epidemological. The knowledge of co-infections of urinary schistosomiasis and other pathogens are important epidemiological tools for the control and health benefits of the rural dwellers. The granulomatous reactions in urinary schistosomiasis is CD4(+) dependent. The CD8(+) is cytotoxic to parasites and it is activated by CD4(+). These parameters therefore participate in the immune responses to urinary schistosomiasis.
objectiveIn this study, we evaluated the polyparasitism involving urinary schistosomiasis and urinary tract co - infections among some rural Nigerians. The CD4(+):CD8(+) ratio and status with age groups in years were also investigated.
methodsParasitological investigation using ova on urine was carried out on 216 volunteers. The urine samples were examined for bacteriuria and subsequently subjected to standard microbiological urine culture. CD4(+)/CD8(+) were determined using the CD T 4 Dynabead techniques. Data were analysed using MicroSoft Excel.
resultsThe inhabitants with light infections of urinary schistosomiasis as indicated by <50 ova /10 ml of urine had a mean CD4(+):CD8(+) ratio of 1.57 while those with heavy infections as shown by >50 ova/10 ml of urine had a relatively lower CD4(+):CD8(+) ratio of 1.03. In all, the overall CD4+:CD8+ ratio of 1.23 was recorded with the mean CD4+ count of 257.96 cells/microL and the mean CD8(+) count of 210.45 cells/microL. Comparatively, the control uninfected subjects had a CD4(+):CD8(+) ratio of 5.97. The CD4(+) and the CD8(+) counts were correlated with the ova of S. haematobium in their urine samples at r = 0.0108 and r = 0.516 respectively. The bacteriuria, urinary schistosomiasis and urinary tract co-infections, namely: Escherichia coli, Proteus, Pseudomonas aeroginosa, Staphylococcus epidermidis and Staph. Saprophyticus were reported in the urine cultures of 48(22.0%) volunteers.
conclusionThe mean overall CD4(+):CD8(+) ratio of urinary schistosomiasis infected persons is 1.23 which is above the normal CD4(+):CD8(+) ratio of 1. The CD4(+):CD8(+) ratio and counts of the urinary schistosomiasis infected inhabitants were lower than the uninfected inhabitants. The positive correlation between the CD4(+):CD8(+) and the S. haematobium ova shows a relationship which indicate an increase of the CD4(+):CD8(+) as the intensity of infection increases. We report polyparasitism of S. haematobium and urinary tracts co-infections among some rural inhabitants in Ikpeshi, Nigeria. It is therefore imperative to incorporate the management of urinary tract infections in urinary schistosomiasis control programme.
Indexed as
Identifiers
16006219PMC1831910W1538550741What OpenQuestion holds
Registered trials
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