ArticleCell and tissue research1992
Development of cytoplasmic digitations between Leydig cells and testicular macrophages of the rat.
Article in Cell and tissue research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 117 citations in OpenAlex.
- The maternal immune response to semen: implications for reproductive success in livestock.Reproduction & fertility · 2026Review
- Testicular macrophages: core immune regulators and emerging therapeutic targets in spermatogenic dysfunction.Frontiers in immunology · 2026Review
- 3D Bioprinted Coaxial Testis Model Using Human Induced Pluripotent Stem Cells:A Step Toward Bicompartmental Cytoarchitecture and Functionalization.Advanced healthcare materials · 2025Article
- SARS-CoV-2 exploits steroidogenic machinery, triggers lipid metabolism for viral replication and induces immune response in Leydig cells of K18-hACE2 mice.Frontiers in cellular and infection microbiology · 2025Article
- Mouse testicular macrophages can independently produce testosterone and are regulated by Cebpb.Biological research · 2024Article
- Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions.Nature communications · 2023Article
- Do macrophages play a role in the adverse effects of endocrine disrupting chemicals (EDCs) on testicular functions?Frontiers in toxicology · 2023Review
- The changing landscape of immune cells in the fetal mouse testis.Histochemistry and cell biology · 2022Article
- Expression ofAnimals : an open access journal from MDPI · 2022Article
- Immune and vascular contributions to organogenesis of the testis and ovary.The FEBS journal · 2022Review
- Testicular Macrophages Produce Progesterone De Novo Promoted by cAMP and Inhibited by M1 Polarization Inducers.Biomedicines · 2022Article
- Eicosanoid Biosynthesis in Male Reproductive Development: Effects of Perinatal Exposure to NSAIDs and Analgesic Drugs.Frontiers in toxicology · 2022Review
- Immune Cells as Critical Regulators of Steroidogenesis in the Testis and Beyond.Frontiers in endocrinology · 2022Review
- Peritubular Macrophages Are Recruited to the Testis of Peripubertal Rats After Mono-(2-Ethylhexyl) Phthalate Exposure and Is Associated With Increases in the Numbers of Spermatogonia.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Macrophages and Stem Cells-Two to Tango for Tissue Repair?Biomolecules · 2021Review
- Review
- Manipulation of spermatogonial stem cells in livestock species.Journal of animal science and biotechnology · 2019Review
- The resident macrophages in murine pancreatic islets are constantly probing their local environment, capturing beta cell granules and blood particles.Diabetologia · 2018Article
- Role of the testis interstitial compartment in spermatogonial stem cell function.Reproduction (Cambridge, England) · 2017Review
- Macrophages in Endocrine Glands, with Emphasis on Pancreatic Islets.Microbiology spectrum · 2016Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Testicular macrophages and Leydig cells from adult animals are known to be functionally coupled. For example, secreted products from macrophages stimulate testosterone secretion by Leydig cells. In adult rat testes, structural coupling also exists between these cells. This coupling consists of cytoplasmic projections from Leydig cells located within cytoplasmic invaginations of macrophages. Although macrophages are known to exist in the testis in immature animals, it is not known when these digitations develop. The purpose of the present study was to determine whether the time of their development coincides with known maturational events that occur in Leydig cells, particularly during the peripubertal period. Testes from rats at 20, 30 and 40-days-of-age as well as testes from mature rats weighing more than 500 gm were prepared for ultrastructural analysis. It was found that digitations form between 20 and 30-days-of-age. These structures varied from simple tubular projections to complicated branched structures, suggesting that digitations are more than simple invaginations of microvilli into coated vesicles as previously described. Subplasmalemmal linear densities were also observed within macrophages juxtaposed to Leydig cells. Collagen was commonly observed between macrophages and Leydig cells in animals 20 days old. These studies demonstrate that although macrophages are present in the testis in maximal numbers at 20 days-of-age, they do not form junctions with Leydig cells until day 30. This is just prior to the major increase in secretory activity of rat Leydig cells that occurs during puberty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.