ReviewHuman genomics2005
The genetics of regulatory variation in the human genome.
Review in Human genomics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Molecular evolution in light of regulatory-coding epistasis.EMBO reports · 2026Review
- Transcriptome variation in human populations and its potential application in forensics.Journal of applied genetics · 2019Review
- Article
- Robust Linear Models for Cis-eQTL Analysis.PloS one · 2015Article
- Integrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer.BMC medical genomics · 2014Article
- Natural variation in the histone demethylase, KDM4C, influences expression levels of specific genes including those that affect cell growth.Genome research · 2014Article
- Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects.BMC genomics · 2012Article
- Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells.American journal of human genetics · 2010Article
- Genetics of human gene expression: mapping DNA variants that influence gene expression.Nature reviews. Genetics · 2009Review
- Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.PLoS genetics · 2008Article
- Gene response profiles for Daphnia pulex exposed to the environmental stressor cadmium reveals novel crustacean metallothioneins.BMC genomics · 2007Article
- Population genomics of human gene expression.Nature genetics · 2007Article
- Genetic variation in human gene expression.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Review
- From DNA to RNA to disease and back: the 'central dogma' of regulatory disease variation.Human genomics · 2006Review
- Normalization using weighted negative second order exponential error functions (NeONORM) provides robustness against asymmetries in comparative transcriptome profiles and avoids false calls.Genomics, proteomics & bioinformatics · 2006Article
- Genome-wide associations of gene expression variation in humans.PLoS genetics · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regulation of gene expression plays an important role in complex phenotypes, including disease in humans. For some genes, the genetic mechanisms influencing gene expression are well elucidated; however, it is unclear how applicable these results are to gene expression on a genome-wide level. Studies in model organisms and humans have clearly documented gene expression variation among individuals and shown that a significant proportion of this variation has a genetic basis. Recent studies combine microarray surveys of gene expression for thousands of genes with dense marker maps, and are beginning to identify regions in the human genome that have functional effects on gene expression. This paper reviews recent developments and methodologies in this field, and discusses implications and future directions of this research in the context of understanding the influence of human genomic variation on the regulation of gene expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.