ReviewHuman genomics2005
Genome-wide scans for loci under selection in humans.
Review in Human genomics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Fitness landscapes of human microsatellites.PLoS genetics · 2024Article
- A Likelihood Approach for Uncovering Selective Sweep Signatures from Haplotype Data.Molecular biology and evolution · 2020Article
- Genomic data reveal a loss of diversity in two species of tuco-tucos (genus Ctenomys) following a volcanic eruption.Scientific reports · 2017Article
- Lactase persistence in Tunisia as a result of admixture with other Mediterranean populations.Genes & nutrition · 2017Article
- Genetic variation and adaptation in Africa: implications for human evolution and disease.Cold Spring Harbor perspectives in biology · 2014Review
- Natural selection and infectious disease in human populations.Nature reviews. Genetics · 2014Review
- Population Genomics of Human Adaptation.Annual review of ecology, evolution, and systematics · 2013Article
- Selection on plant male function genes identifies candidates for reproductive isolation of yellow monkeyflowers.PLoS genetics · 2013Article
- Personal receptor repertoires: olfaction as a model.BMC genomics · 2012Article
- Human evolutionary genomics: ethical and interpretive issues.Trends in genetics : TIG · 2012Review
- Scanning for genomic regions subject to selective sweeps using SNP-MaP strategy.Genomics, proteomics & bioinformatics · 2010Article
- A powerful score test to detect positive selection in genome-wide scans.European journal of human genetics : EJHG · 2010Article
- SNP@Evolution: a hierarchical database of positive selection on the human genome.BMC evolutionary biology · 2009Article
- Constructing genomic maps of positive selection in humans: where do we go from here?Genome research · 2009Article
- Darwinian and demographic forces affecting human protein coding genes.Genome research · 2009Article
- Contrasting evolution of diversity at two disease-associated chicken genes.Immunogenetics · 2009Article
- Strategies for reliable exploitation of evolutionary concepts in high throughput biology.Evolutionary bioinformatics online · 2008Article
- Bayesian variable selection for detecting adaptive genomic differences among populations.Genetics · 2008Article
- A new approach for using genome scans to detect recent positive selection in the human genome.PLoS biology · 2007Article
- Bayesian estimates of linkage disequilibrium.BMC genetics · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural selection, which can be defined as the differential contribution of genetic variants to future generations, is the driving force of Darwinian evolution. Identifying regions of the human genome that have been targets of natural selection is an important step in clarifying human evolutionary history and understanding how genetic variation results in phenotypic diversity, it may also facilitate the search for complex disease genes. Technological advances in high-throughput DNA sequencing and single nucleotide polymorphism genotyping have enabled several genome-wide scans of natural selection to be undertaken. Here, some of the observations that are beginning to emerge from these studies will be reviewed, including evidence for geographically restricted selective pressures (ie local adaptation) and a relationship between genes subject to natural selection and human disease. In addition, the paper will highlight several important problems that need to be addressed in future genome-wide studies of natural selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.