ArticleJournal of muscle research and cell motility2005
Effects of the compact mutant myostatin allele Mstn (Cmpt-dl1Abc) introgressed into a high growth mouse line on skeletal muscle cellularity.
Article in Journal of muscle research and cell motility, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Trial
- 3D skeletal muscle model recapitulating the myostatin knockout phenotypic and mitochondrial metabolic features.Physiological reports · 2026Article
- Myostatin Knockout Mice Have Larger Muscle Fibers With Normal Function and Morphology.Muscle & nerve · 2025Article
- Article
- Polymorphism of Genes and Their Impact on Beef Quality.Current issues in molecular biology · 2023Review
- Combinatorial Inhibition of Myostatin and Activin A Improves Femoral Bone Properties in the G610C Mouse Model of Osteogenesis Imperfecta.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- The Possible Role of Complete Loss of Myostatin in Limiting Excessive Proliferation of Muscle Cells (C2C12) via Activation of MicroRNAs.International journal of molecular sciences · 2019Article
- Fine-mapping of genes determining extrafusal fiber properties in murine soleus muscle.Physiological genomics · 2017Article
- Role of IGF-I in follistatin-induced skeletal muscle hypertrophy.American journal of physiology. Endocrinology and metabolism · 2015Article
- Skeletal muscle cellularity and glycogen distribution in the hypermuscular Compact mice.European journal of histochemistry : EJH · 2014Article
- ROCK inhibition as a therapy for spinal muscular atrophy: understanding the repercussions on multiple cellular targets.Frontiers in neuroscience · 2014Review
- The compact mutation of myostatin causes a glycolytic shift in the phenotype of fast skeletal muscles.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- Increasing muscle mass to improve metabolism.Adipocyte · 2013Article
- Enhanced sensitivity of skeletal muscle growth in offspring of mice long-term selected for high body mass in response to a maternal high-protein/low-carbohydrate diet during lactation.European journal of nutrition · 2013Article
- Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.BMC medicine · 2012Article
- Hindlimb skeletal muscle function in myostatin-deficient mice.Muscle & nerve · 2011Article
- QTL Analysis of Type I and Type IIA Fibers in Soleus Muscle in a Cross between LG/J and SM/J Mouse Strains.Frontiers in genetics · 2011Article
- Myostatin knockout mice increase oxidative muscle phenotype as an adaptive response to exercise.Journal of muscle research and cell motility · 2010Article
- Functional assessment of skeletal muscle in intact mice lacking myostatin by concurrent NMR imaging and spectroscopy.Gene therapy · 2010Article
- Lack of myostatin results in excessive muscle growth but impaired force generation.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The murine myostatin mutation Mstn(Cmpt-dl1Abc) (Compact; C) was introduced into an inbred mouse line with extreme growth (DUHi) by marker-assisted introgression. To study the allelic effects on muscle fibre hyperplasia and hypertrophy, myonuclear proliferation, protein accretion, capillary density, and muscle fibre metabolism, samples from M. rectus femoris (RF) and M. longissimus dorsi (LD) muscles of animals wild-type (+/+), heterozygous (C/+), and homozygous (C/C) for the Mstn(Cmpt-dl1Abc) allele were examined by histological and biochemical analyses. Homozygous C/C mice exhibited lower body (-12%) but higher muscle weights (+38%) than ++ mice. Total muscle fibre number was increased (+24%), whereas fibre size was not significantly affected. Protein and DNA concentrations and DNA:protein ratios as well as specific CK activity remained unchanged for higher mass muscle implying increases in the total contents of DNA and muscle specific protein. Fibre type distribution was markedly shifted to the white glycolytic muscle fibres (+16-17% units) at the expense of red oxidative fibres. Capillary density was substantially lower in C/C than in ++ mice as seen by lower number of capillaries per fibre (-35%) and larger fibre area per capillary (+77%). However, the Mstn(Cmpt-dl1Abc) allele was partially recessive in heterozygous C/+ mice for both fibre type frequencies and capillary density. The results show that hypermuscularity caused by mutations in the myostatin gene results from muscle fibre hyperplasia rather than hypertrophy, and from balanced increases in myonuclear proliferation and protein accretion. However, capillary supply is adversely affected and muscle metabolism shifted towards glycolysis, which could have negative consequences for physical fitness.
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