ArticleClinical and diagnostic laboratory immunology2005
Clinical and immunological features of 65 Iranian patients with common variable immunodeficiency.
Article in Clinical and diagnostic laboratory immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 141 citations in OpenAlex.
- Classification of common variable immunodeficiency through immunological and clinical phenotyping in Moroccan patients.Qatar medical journal · 2023Article
- Primary antibody deficiencies in Turkey: molecular and clinical aspects.Immunologic research · 2022Article
- Bowel Histology of CVID Patients Reveals Distinct Patterns of Mucosal Inflammation.Journal of clinical immunology · 2022Article
- Common variable immunodeficiency disorders: What generalists should know.African journal of thoracic and critical care medicine · 2021Review
- Altered Microbiota, Impaired Quality of Life, Malabsorption, Infection, and Inflammation in CVID Patients With Diarrhoea.Frontiers in immunology · 2020Article
- Evaluation of Clinical and Immunological Characteristics of Children with Common Variable Immunodeficiency.International journal of pediatrics · 2018Article
- Article
- Cancers Related to Immunodeficiencies: Update and Perspectives.Frontiers in immunology · 2016Review
- Intestinal Amyloidosis in Common Variable Immunodeficiency and Rheumatoid Arthritis.Case reports in gastrointestinal medicine · 2015Article
- Ocular involvement in primary immunodeficiency diseases.Journal of clinical immunology · 2014Review
- Expression of activation-induced cytidine deaminase gene in B lymphocytes of patients with common variable immunodeficiency.Iranian journal of pediatrics · 2013Article
- The spectrum of disease manifestations in patients with common variable immunodeficiency disorders and partial antibody deficiency in a university hospital.Journal of clinical immunology · 2012Article
- Common variable immunodeficiency: an update.Arthritis research & therapy · 2012Review
- Utility of peripheral blood B cell subsets analysis in common variable immunodeficiency.Clinical and experimental immunology · 2012Article
- A rare cause of secondary amyloidosis: common variable immunodeficiency disease.Case reports in nephrology · 2012Article
- Serum bactericidal antibody response 1 year after meningococcal polysaccharide vaccination of patients with common variable immunodeficiency.Clinical and vaccine immunology : CVI · 2010Article
- History of primary immunodeficiency diseases in iran.Iranian journal of pediatrics · 2010Article
- Mannose-binding lectin polymorphisms in common variable immunodeficiency.Clinical and experimental medicine · 2009Article
- Novel mutations in TACI (TNFRSF13B) causing common variable immunodeficiency.Journal of clinical immunology · 2009Article
- Proinflammatory cytokine gene single nucleotide polymorphisms in common variable immunodeficiency.Clinical and experimental immunology · 2009Article
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Common variable immunodeficiency (CVID) is a primary immunodeficiency disease characterized by hypogammaglobulinemia and recurrent bacterial infections. The records of 65 patients with CVID (37 males and 28 females) in the age range of 24 to 537 months were reviewed. By the year 2003, 11 patients had died and seven patients could not be located. The total follow-up period was 221 patient-years. The median diagnostic delay (time between onset and diagnosis) in our patient group was 60 months. At the time of diagnosis, the baseline serum immunoglobulin G (IgG), IgM, and IgA levels were below the level normal for the patients' age; the medians for this group were 120, 10, and 0 mg/dl, respectively. All of the patients presented with infectious diseases at the time of onset, the most common of which were otitis media, diarrhea, pneumonia, and sinusitis. Acute and recurrent infections were also found in almost all of the patients, particularly involving respiratory and gastrointestinal systems. The most common infections, before diagnosis and during follow-up, were pneumonia, acute diarrhea, acute sinusitis, and otitis media. CVID should be considered in any patient with a history of recurrent infections and decreased levels of all serum immunoglobulin isotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.