Evidence map›Paper›PMID 16002623›Full record

ReviewAmerican journal of physiology. Cell physiology2005

Nonviral gene transfer to skeletal, smooth, and cardiac muscle in living animals.

David A Dean

Abstract readReview
In one paragraph

Review in American journal of physiology. Cell physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Therapeutic promise of engineered nonsense suppressor tRNAs.Wiley interdisciplinary reviews. RNA · 2021
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Human erythropoietin gene delivery for cardiac remodeling of myocardial infarction in rats.Journal of controlled release : official journal of the Controlled Release Society · 2013
    Article
  10. Article
  11. Hyperactive self-inactivating piggyBac for transposase-enhanced pronuclear microinjection transgenesis.Proceedings of the National Academy of Sciences of the United States of America · 2012
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Electroporation-mediated gene transfer of the Na+,K+ -ATPase rescues endotoxin-induced lung injury.American journal of respiratory and critical care medicine · 2007
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

David A DeanDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern Univ., 240 E. Huron Ave., McGaw 2336, Chicago, IL 60611, USA. dean@northwestern.edu

Funding

Role of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHANDEL, NAVDEEP S · 2003 to 2019
$30.8M
VASCULAR SMOOTH MUSCLE SPECIFIC GENE THERAPY VECTORSR01HL059956 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI DEAN, DAVID A · 1998 to 2007
$1.8M
NHLBI NIH HHS HL-59956NHLBI NIH HHS HL-71643NHLBI NIH HHS P01 HL071643NHLBI NIH HHS R01 HL059956
6 · The paper itself

Abstract

The study of muscle physiology has undergone many changes over the past 25 years and has moved from purely physiological studies to those intimately intertwined with molecular and cell biological questions. To ask these questions, it is necessary to be able to transfer genetic reagents to cells both in culture and, ultimately, in living animals. Over the past 10 years, a number of different chemical and physical approaches have been developed to transfect living skeletal, smooth, and cardiac muscle systems with varying success and efficiency. This review provides a survey of these methods and describes some more recent developments in the field of in vivo gene transfer to these various muscle types. Both gene delivery for overexpression of desired gene products and delivery of nucleic acids for downregulation of specific genes and their products are discussed to aid the physiologist, cell biologist, and molecular biologist in their studies on whole animal biology.

Indexed as

Gene Transfer TechniquesMyocardiumAnimalsElectroporationMuscle, SkeletalMuscle, SmoothTransfection

Identifiers

PMID16002623
PMCPMC4152902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.