ArticleProceedings of the National Academy of Sciences of the United States of America2005
Adult mouse brain gene expression patterns bear an embryologic imprint.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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Who cites it
105 citing papers in PubMed.
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- Single-cell profiling of glial cells from the mouse amygdala under opioid dependent and withdrawal states.iScience · 2023Article
- Towards reliable reconstruction of the mouse brain corticothalamic connectivity using diffusion MRI.NeuroImage · 2023Article
- Adult expression of Semaphorins and Plexins is essential for motor neuron survival.Scientific reports · 2023Article
- Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission to Participate in Fentanyl-Induced Hyperalgesia in Rats.Cellular and molecular neurobiology · 2023Article
- A protein-coding gene expression atlas from the brain of pregnant and non-pregnant goats.Frontiers in genetics · 2023Article
- Sex-specific transcriptomic and epitranscriptomic signatures of PTSD-like fear acquisition.iScience · 2022Article
- The Modification of Offspring Stress-Related Behavior and the Expression ofInternational journal of molecular sciences · 2022Article
- Neurobehavioral abnormalities following prenatal psychosocial stress are differentially modulated by maternal environment.Translational psychiatry · 2022Article
- Peripheral interleukin-6-associated microglial QUIN elevation in basolateral amygdala contributed to cognitive dysfunction in a mouse model of postoperative delirium.Frontiers in medicine · 2022Article
- CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake.Molecular psychiatry · 2021Article
- A novel arousal-based individual screening reveals susceptibility and resilience to PTSD-like phenotypes in mice.Neurobiology of stress · 2021Article
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- StandardizedAntioxidants (Basel, Switzerland) · 2020Article
- Genetic Contributions to Multivariate Data-Driven Brain Networks Constructed via Source-Based Morphometry.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Regional transcriptome analysis of AMPA and GABAScientific reports · 2020Article
45 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors.
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Abstract
The current model to explain the organization of the mammalian nervous system is based on studies of anatomy, embryology, and evolution. To further investigate the molecular organization of the adult mammalian brain, we have built a gene expression-based brain map. We measured gene expression patterns for 24 neural tissues covering the mouse central nervous system and found, surprisingly, that the adult brain bears a transcriptional "imprint" consistent with both embryological origins and classic evolutionary relationships. Embryonic cellular position along the anterior-posterior axis of the neural tube was shown to be closely associated with, and possibly a determinant of, the gene expression patterns in adult structures. We also observed a significant number of embryonic patterning and homeobox genes with region-specific expression in the adult nervous system. The relationships between global expression patterns for different anatomical regions and the nature of the observed region-specific genes suggest that the adult brain retains a degree of overall gene expression established during embryogenesis that is important for regional specificity and the functional relationships between regions in the adult. The complete collection of extensively annotated gene expression data along with data mining and visualization tools have been made available on a publicly accessible web site (www.barlow-lockhart-brainmapnimhgrant.org).
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