Evidence map›Paper›PMID 16002437›Full record

ArticleThe Journal of physiology2005

Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise.

Benjamin F Miller, Jens L Olesen, Mette Hansen, Simon Døssing, Regina M Crameri, Rasmus J Welling, Henning Langberg, Allan Flyvbjerg, Michael Kjaer, John A Babraj and 2 more

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 251 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
251citing papers in PubMed, 7 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03779737 nacompletednot on this mapstarted 2016, after this paper: background citation

Muscular Strength and Aerobic Capacity, a Symbiotic Relationship With Birth Weight and Metabolic Risk of Colombian Scholchildren: Study SIMAC

TypeinterventionalSponsorFundación Oftalmológica de Santander Clínica Carlos Ardila LulleRan2016 to 2016Enrolled150ConditionsResistance Training, Cardiovascular Risk, Low Birth WeightArmsMuscular Resistance training, Cardiorespiratory training, Habitual training
NCT04596553 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effects of Essential and Non-Essential Amino Acids on Post-Exercise Muscle Collagen Synthesis in Young Men: a Randomized Controlled Trial

TypeinterventionalSponsorUniversity of British ColumbiaRan2021 to 2022Enrolled17ConditionsSkeletal Muscle, Extracellular Matrix, Amino Acids Metabolism, ExerciseArmsEssential Amino Acid, Collagen Peptide, Maltodextrin Placebo
3 · Its place in the literature

Who cites it

251 citing papers in PubMed, 7 syntheses or guidelines pooled it, 594 citations in OpenAlex.

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  18. The Effects of Eccentric Contraction Execution Time on the Properties of the Patellar Tendon.International journal of environmental research and public health · 2022
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191 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Benjamin F MillerInstitute of Sports Medicine, Copenhagen, Bispebjerg Hospital, Denmark.
Jens L Olesen
Mette Hansen
Simon Døssing
Regina M Crameri
Rasmus J Welling
Henning Langberg
Allan Flyvbjerg
Michael Kjaer
John A Babraj
Kenneth Smith
Michael J Rennie
Bispebjerg Hospital · DKUniversity of Nottingham · GBAarhus University Hospital · DKUniversity of Dundee · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

We hypothesized that an acute bout of strenuous, non-damaging exercise would increase rates of protein synthesis of collagen in tendon and skeletal muscle but these would be less than those of muscle myofibrillar and sarcoplasmic proteins. Two groups (n = 8 and 6) of healthy young men were studied over 72 h after 1 h of one-legged kicking exercise at 67% of maximum workload (W(max)). To label tissue proteins in muscle and tendon primed, constant infusions of [1-(13)C]leucine or [1-(13)C]valine and flooding doses of [(15)N] or [(13)C]proline were given intravenously, with estimation of labelling in target proteins by gas chromatography-mass spectrometry. Patellar tendon and quadriceps biopsies were taken in exercised and rested legs at 6, 24, 42 or 48 and 72 h after exercise. The fractional synthetic rates of all proteins were elevated at 6 h and rose rapidly to peak at 24 h post exercise (tendon collagen (0.077% h(-1)), muscle collagen (0.054% h(-1)), myofibrillar protein (0.121% h(-1)), and sarcoplasmic protein (0.134% h(-1))). The rates decreased toward basal values by 72 h although rates of tendon collagen and myofibrillar protein synthesis remained elevated. There was no tissue damage of muscle visible on histological evaluation. Neither tissue microdialysate nor serum concentrations of IGF-I and IGF binding proteins (IGFBP-3 and IGFBP-4) or procollagen type I N-terminal propeptide changed from resting values. Thus, there is a rapid increase in collagen synthesis after strenuous exercise in human tendon and muscle. The similar time course of changes of protein synthetic rates in different cell types supports the idea of coordinated musculotendinous adaptation.

Indexed as

AdultCarbon RadioisotopesCollagenExerciseHemiterpenesHumansKeto AcidsLeucineMaleMuscle ProteinsMuscle, SkeletalMyofibrilsNitrogen RadioisotopesPatellaProlineSarcoplasmic Reticulumalpha-ketoisocaproic acidalpha-ketoisovalerateCarbon RadioisotopesCollagenHemiterpenesKeto AcidsLeucineMuscle ProteinsNitrogen RadioisotopesProlineValine

Identifiers

PMID16002437
PMCPMC1474228
OpenAlexW2123852369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.