ArticleApplied and environmental microbiology2005
Algal viruses with distinct intraspecies host specificities include identical intein elements.
Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- Functional polyamine metabolic enzymes and pathways encoded by the virosphere.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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- Diversity and genomics of giant viruses in the North Pacific Subtropical Gyre.Frontiers in microbiology · 2022Article
- Communities of Phytoplankton Viruses across the Transition Zone of the St. Lawrence Estuary.Viruses · 2018Article
- Article
- The dynamic intein landscape of eukaryotes.Mobile DNA · 2018Article
- Article
- Complete Genome Sequence of a Phycodnavirus, Heterosigma akashiwo Virus Strain 53.Genome announcements · 2016Article
- Intein Clustering Suggests Functional Importance in Different Domains of Life.Molecular biology and evolution · 2016Article
- Evolution and Phylogeny of Large DNA Viruses,Frontiers in microbiology · 2016Article
- Evolution and Application of Inteins inFrontiers in microbiology · 2016Review
- Enigmatic distribution, evolution, and function of inteins.The Journal of biological chemistry · 2014Review
- Unveiling of the diversity of Prasinoviruses (Phycodnaviridae) in marine samples by using high-throughput sequencing analyses of PCR-amplified DNA polymerase and major capsid protein genes.Applied and environmental microbiology · 2014Article
- Gene invasion in distant eukaryotic lineages: discovery of mutually exclusive genetic elements reveals marine biodiversity.The ISME journal · 2013Article
- Prasinoviruses of the marine green alga Ostreococcus tauri are mainly species specific.Journal of virology · 2012Article
- Virophage control of antarctic algal host-virus dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Giant virus with a remarkable complement of genes infects marine zooplankton.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Remarkable sequence similarity between the dinoflagellate-infecting marine girus and the terrestrial pathogen African swine fever virus.Virology journal · 2009Article
- Virioplankton abundance in trophic gradients of an upwelling field.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2009Article
- The Phycodnaviridae: the story of how tiny giants rule the world.Current topics in microbiology and immunology · 2009Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterosigma akashiwo virus (HaV) is a large double-stranded DNA virus infecting the single-cell bloom-forming raphidophyte (golden brown alga) H. akashiwo. A molecular phylogenetic sequence analysis of HaV DNA polymerase showed that it forms a sister group with Phycodnaviridae algal viruses. All 10 examined HaV strains, which had distinct intraspecies host specificities, included an intein (protein intron) in their DNA polymerase genes. The 232-amino-acid inteins differed from each other by no more than a single nucleotide change. All inteins were present at the same conserved position, coding for an active-site motif, which also includes inteins in mimivirus (a very large double-stranded DNA virus of amoebae) and in several archaeal DNA polymerase genes. The HaV intein is closely related to the mimivirus intein, and both are apparently monophyletic to the archaeal inteins. These observations suggest the occurrence of horizontal transfers of inteins between viruses of different families and between archaea and viruses and reveal that viruses might be reservoirs and intermediates in horizontal transmissions of inteins. The homing endonuclease domain of the HaV intein alleles is mostly deleted. The mechanism keeping their sequences basically identical in HaV strains specific for different hosts is yet unknown. One possibility is that rapid and local changes in the HaV genome change its host specificity. This is the first report of inteins found in viruses infecting eukaryotic algae.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.