ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Synapse-specific regulation of AMPA receptor subunit composition by activity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 76 citations in OpenAlex.
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- The Shaping of AMPA Receptor Surface Distribution by Neuronal Activity.Frontiers in synaptic neuroscience · 2022Review
- Immunohistochemical detection of GluA1 subunit of AMPA receptor in the rat nucleus accumbens following cocaine exposure.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021Article
- Activity Dependent and Independent Determinants of Synaptic Size Diversity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
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- Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Illuminating the multifaceted roles of neurotransmission in shaping neuronal circuitry.Neuron · 2014Review
- Evidence of calcium-permeable AMPA receptors in dendritic spines of CA1 pyramidal neurons.Journal of neurophysiology · 2014Article
- Interplay of cell-autonomous and nonautonomous mechanisms tailors synaptic connectivity of converging axons in vivo.Neuron · 2014Article
- Investigation of synapse formation and function in a glutamatergic-GABAergic two-neuron microcircuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Involvement of ClC-3 chloride/proton exchangers in controlling glutamatergic synaptic strength in cultured hippocampal neurons.Frontiers in cellular neuroscience · 2014Article
- The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity.Frontiers in cellular neuroscience · 2014Review
- Decreased dendritic spine density as a consequence of tetanus toxin light chain expression in single neurons in vivo.Neuroscience letters · 2013Article
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3 authors at 3 institutions in 2 countries.
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Abstract
We examined the changes that arise when neurotransmitter release is inhibited in a subpopulation of hippocampal neurons in coculture with normally active neighbors. Subsets of neurons were presynaptically silenced by chronic expression of tetanus toxin light chain tagged with cyan fluorescent protein (TNTCFP). Surprisingly, silenced neurons formed as many presynaptic terminals as their active neighbors when grown together on glial microislands. However, silenced neurons could not recruit the AMPA-type glutamate receptor subunit GluR1 as efficiently when competing with active neighbors. The immunofluorescence intensity ratio of GluR1 at synaptic puncta versus shaft was reduced by 22% opposite TNTCFP-expressing terminals compared with active neighbors. In contrast, this effect is abolished when vesicular release is blocked in all neurons. Local presynaptic inhibition by TNTCFP did not change the synaptic level of the AMPA receptor subunits GluR2 or GluR2/3 or of the PSD95 (postsynaptic density 95) family scaffolding proteins. Thus, neurotransmitter release selectively regulates the AMPA receptor population on a synapse-by-synapse basis but is not essential for an axon to efficiently compete for synaptic territory in a simple model system. These results demonstrate precise input specificity of postsynaptic receptor composition via differential activity among neighbor synapses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.