ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Globus pallidus neurons dynamically regulate the activity pattern of subthalamic nucleus neurons through the frequency-dependent activation of postsynaptic GABAA and GABAB receptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 88 citations in OpenAlex.
- A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping.Nature communications · 2024Article
- Movement-related increases in subthalamic activity optimize locomotion.Cell reports · 2024Article
- Pallidal GABA B receptors: involvement in cortex beta dynamics and thalamic reticular nucleus activity.The journal of physiological sciences : JPS · 2023Article
- Spontaneous Activity of the Local GABAergic Synaptic Network Causes Irregular Neuronal Firing in the External Globus Pallidus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Differential modulation of subthalamic projection neurons by short-term and long-term electrical stimulation in physiological and parkinsonian conditions.Acta pharmacologica Sinica · 2022Article
- Dysregulation of the Basal Ganglia Indirect Pathway in Early SymptomaticThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- GABACurrent topics in behavioral neurosciences · 2022Article
- Cortical Control of Subthalamic Neuronal Activity through the Hyperdirect and Indirect Pathways in Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Dysregulation of external globus pallidus-subthalamic nucleus network dynamics in parkinsonian mice during cortical slow-wave activity and activation.The Journal of physiology · 2020Article
- Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping out of the Striatum.Cells · 2019Review
- Beta-Band Resonance and Intrinsic Oscillations in a Biophysically Detailed Model of the Subthalamic Nucleus-Globus Pallidus Network.Frontiers in computational neuroscience · 2019Article
- Cyclic AMP-producing chemogenetic activation of indirect pathway striatal projection neurons and the downstream effects on the globus pallidus and subthalamic nucleus in freely moving mice.Journal of neurochemistry · 2018Article
- Neuronal inhibition and synaptic plasticity of basal ganglia neurons in Parkinson's disease.Brain : a journal of neurology · 2018Article
- Heterosynaptic regulation of external globus pallidus inputs to the subthalamic nucleus by the motor cortex.Neuron · 2015Article
- Article
- Animal models of tic disorders: a translational perspective.Journal of neuroscience methods · 2014Review
- New roles for the external globus pallidus in basal ganglia circuits and behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Review
- Localization and function of dopamine receptors in the subthalamic nucleus of normal and parkinsonian monkeys.Journal of neurophysiology · 2014Article
- Short-term depression of external globus pallidus-subthalamic nucleus synaptic transmission and implications for patterning subthalamic activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Simulating the effects of short-term synaptic plasticity on postsynaptic dynamics in the globus pallidus.Frontiers in systems neuroscience · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Reciprocally connected GABAergic neurons of the globus pallidus (GP) and glutamatergic neurons of the subthalamic nucleus (STN) are a putative generator of pathological rhythmic burst firing in Parkinson's disease (PD). Burst firing of STN neurons may be driven by rebound depolarization after barrages of GABA(A) receptor (GABA(A)R)-mediated IPSPs arising from pallidal fibers. To determine the conditions under which pallidosubthalamic transmission activates these and other postsynaptic GABARs, a parasagittal mouse brain slice preparation was developed in which pallidosubthalamic connections were preserved. Intact connectivity was first confirmed through the injection of a neuronal tracer into the GP. Voltage-clamp and gramicidin-based perforated-patch current-clamp recordings were then used to study the relative influences of GABA(A)R- and GABA(B)R-mediated pallidosubthalamic transmission on STN neurons. Spontaneous phasic, but not tonic, activation of postsynaptic GABA(A)Rs reduced the frequency and disrupted the rhythmicity of autonomous firing in STN neurons. However, postsynaptic GABA(B)Rs were only sufficiently activated to impact STN firing when pallidosubthalamic transmission was elevated or pallidal fibers were synchronously activated by electrical stimulation. In a subset of neurons, rebound burst depolarizations followed high-frequency, synchronous stimulation of pallidosubthalamic fibers. Although GABA(B)R-mediated hyperpolarization was itself sufficient to generate rebound bursts, coincident activation of postsynaptic GABA(A)Rs produced longer and more intense burst firing. These findings elucidate a novel route through which burst activity can be generated in the STN, and suggest that GABARs on STN neurons could act in a synergistic manner to generate abnormal burst activity in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.