ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Pathological aggression in "fierce" mice corrected by human nuclear receptor 2E1.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
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- Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage.Journal of genetics and genomics = Yi chuan xue bao · 2022Article
- The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Xanthines.ACS pharmacology & translational science · 2021Article
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- Aberrant transcriptomes and DNA methylomes define pathways that drive pathogenesis and loss of brain laterality/asymmetry in schizophrenia and bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- Cross-species systems analysis of evolutionary toolkits of neurogenomic response to social challenge.Genes, brain, and behavior · 2019Article
- Co-activator candidate interactions for orphan nuclear receptor NR2E1.BMC genomics · 2016Article
- The Orphan Nuclear Receptor TLX/NR2E1 in Neural Stem Cells and Diseases.Neuroscience bulletin · 2016Review
- Of Fighting Flies, Mice, and Men: Are Some of the Molecular and Neuronal Mechanisms of Aggression Universal in the Animal Kingdom?PLoS genetics · 2015Review
- Nr2e1 regulates retinal lamination and the development of Müller glia, S-cones, and glycineric amacrine cells during retinogenesis.Molecular brain · 2015Article
- Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases.Journal of experimental neuroscience · 2015Review
- Effects of let-7b and TLX on the proliferation and differentiation of retinal progenitor cells in vitro.Scientific reports · 2014Article
- The nuclear receptor gene family in the Pacific oyster, Crassostrea gigas, contains a novel subfamily group.BMC genomics · 2014Article
- Minireview: the role of nuclear receptors in photoreceptor differentiation and disease.Molecular endocrinology (Baltimore, Md.) · 2012Review
- Retina restored and brain abnormalities ameliorated by single-copy knock-in of human NR2E1 in null mice.Molecular and cellular biology · 2012Article
- Article
- Modelling human regulatory variation in mouse: finding the function in genome-wide association studies and whole-genome sequencing.PLoS genetics · 2012Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
"Fierce" mice, homozygous for the deletion of nuclear receptor 2E1 (NR2E1), show abnormal brain-eye development and pathological aggression. To evaluate functional equivalency between mouse and human NR2E1, we generated mice transgenic for a genomic clone spanning the human NR2E1 locus and bred these animals to fierce mice deleted for the corresponding mouse gene. In fierce mutants carrying human NR2E1, structural brain defects were eliminated and eye abnormalities ameliorated. Excitingly, behavior in these "rescue" mice was indistinguishable from controls. Because no artificial promoter was used to drive transgene expression, promoter and regulatory elements within the human NR2E1 clone are functional in mouse. Normal behavior in rescue animals suggests that mechanisms underlying the behavioral abnormalities in fierce mice may also be conserved in humans. Our data support the hypothesis that variation at NR2E1 may contribute to human behavioral disorders. Use of this rescue paradigm with other genes will permit the direct evaluation of human genes hypothesized to play a causal role in psychiatric disease but for which evidence is lacking or equivocal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.