ArticleProceedings of the National Academy of Sciences of the United States of America2005
An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects.Scientific reports · 2021Article
- Sphingosine kinases protect murine embryonic stem cells from sphingosine-induced cell cycle arrest.Stem cells (Dayton, Ohio) · 2020Article
- The role of telomere-binding modulators in pluripotent stem cells.Protein & cell · 2020Review
- The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells.Experimental cell research · 2017Article
- A balance between elongation and trimming regulates telomere stability in stem cells.Nature structural & molecular biology · 2017Article
- Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.The EMBO journal · 2015Article
- Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells.Scientific reports · 2015Article
- Defective repair of uracil causes telomere defects in mouse hematopoietic cells.The Journal of biological chemistry · 2015Article
- Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma.Nature genetics · 2014Article
- Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation.Cell research · 2013Article
- Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells.Cell research · 2012Article
- The breast cancer susceptibility gene BRCA2 is required for the maintenance of telomere homeostasis.The Journal of biological chemistry · 2012Article
- The long and short of it: the role of telomeres in fetal origins of adult disease.Journal of pregnancy · 2012Review
- Association of telomere length with authentic pluripotency of ES/iPS cells.Cell research · 2011Article
- Article
- Characterization of oxidative guanine damage and repair in mammalian telomeres.PLoS genetics · 2010Article
- Article
- FANCC suppresses short telomere-initiated telomere sister chromatid exchange.Human molecular genetics · 2010Article
- Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging.Biogerontology · 2009Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Telomerase deficiency leads to a progressive loss of telomeric DNA that eventually triggers cell apoptosis in human primary cells during prolonged growth in culture. Rare survivors can maintain telomere length through either activation of telomerase or recombination-based telomere lengthening, and thus proliferate indefinitely. We have explored the possibility that telomeres may be maintained through telomere sister chromatid exchange (T-SCE) in murine telomere reverse transcriptase-deficient (mTert-/-) splenocytes and ES cells. Because telomerase deficiency leads to gradual loss of telomeric DNA in mTert-/- splenocytes and ES cells and eventually to chromosomes with telomere signal-free ends (SFEs), we examined these cell types for evidence of sister chromatid exchange at telomeres, and observed an increase in T-SCEs only in a subset of mTert-/- splenocytes or ES cells that possessed multiple SFEs. Furthermore, T-SCEs were more often detected in ES cells than in splenocytes that harbored a similar frequency of SFEs. In mTert heterozygous (mTert+/-) ES cells or splenocytes, which are known to exhibit a decrease in average telomere length but no SFEs, no increase in T-SCE was observed. In addition to T-SCE, other genomic rearrangements (i.e., SCE) were also significantly increased in mTert-/- ES cells possessing critically short telomeres, but not in splenocytes. Our results suggest that animals and cell culture differ in their ability to carry out genomic rearrangements as a means of maintaining telomere integrity when telomeres become critically shortened.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.