ArticleJournal of neurochemistry2005
RanBPM is an L1-interacting protein that regulates L1-mediated mitogen-activated protein kinase activation.
Article in Journal of neurochemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- L1 Cell Adhesion Molecule in Cancer, a Systematic Review on Domain-Specific Functions.International journal of molecular sciences · 2019Pooled it
- A role for the Erk MAPK pathway in modulating SAX-7/L1CAM-dependent locomotion in Caenorhabditis elegans.Genetics · 2022Article
- The Life of a Trailing Spouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Review
- RANBP9 as potential therapeutic target in non-small cell lung cancer.Journal of cancer metastasis and treatment · 2020Article
- L1CAM is involved in lymph node metastasis via ERK1/2 signaling in colorectal cancer.American journal of translational research · 2020Article
- The CTLH Complex in Cancer Cell Plasticity.Journal of oncology · 2019Review
- L1CAM drives oncogenicity in esophageal squamous cell carcinoma by stimulation of ezrin transcription.Journal of molecular medicine (Berlin, Germany) · 2017Article
- Cell signalling pathway regulation by RanBPM: molecular insights and disease implications.Open biology · 2017Review
- Ran-dependent TPX2 activation promotes acentrosomal microtubule nucleation in neurons.Scientific reports · 2017Article
- Cell Recognition Molecule L1 Regulates Cell Surface Glycosylation to Modulate Cell Survival and Migration.International journal of medical sciences · 2017Article
- Review
- COPS5 protein overexpression increases amyloid plaque burden, decreases spinophilin-immunoreactive puncta, and exacerbates learning and memory deficits in the mouse brain.The Journal of biological chemistry · 2015Article
- Characterization of RanBPM molecular determinants that control its subcellular localization.PloS one · 2015Article
- RAN-binding protein 9 is involved in alternative splicing and is critical for male germ cell development and male fertility.PLoS genetics · 2014Article
- RanBP9 overexpression reduces dendritic arbor and spine density.Neuroscience · 2014Article
- Downregulation of L1CAM inhibits proliferation, invasion and arrests cell cycle progression in pancreatic cancer cellsExperimental and therapeutic medicine · 2014Article
- RanBP9 overexpression accelerates loss of pre and postsynaptic proteins in the APΔE9 transgenic mouse brain.PloS one · 2014Article
- The emerging role of class-3 semaphorins and their neuropilin receptors in oncology.OncoTargets and therapy · 2014Review
- RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility.The Journal of biological chemistry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A yeast two-hybrid screen using the last 28 amino acids of the cytoplasmic domain of the neural cell adhesion molecule L1 identified RanBPM as an L1-interacting protein. RanBPM associates with L1 in vivo and the N-terminal region of RanBPM (N-RanBPM), containing the SPRY domain, is sufficient for the interaction with L1 in a glutathione S-transferase pull-down assay. L1 antibody patching dramatically changes the subcellular localization of N-RanBPM in transfected COS cells. Overexpression of N-RanBPM in COS cells reduces L1-triggered extracellular signal-regulated kinase 1/2 activation by 50% and overexpression of N-RanBPM in primary neurons inhibits L1-mediated neurite outgrowth and branching. These data suggest that RanBPM is an adaptor protein that links L1 to the extracellular signal-regulated kinase/MAPK pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.