ArticleJournal of neurochemistry2005
AMPA receptor stimulation increases alpha5beta1 integrin surface expression, adhesive function and signaling.
Article in Journal of neurochemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Plant toxin β-ODAP activates integrin β1 and focal adhesion: A critical pathway to cause neurolathyrism.Scientific reports · 2017Article
- Integrin Activation Through the Hematopoietic Adapter Molecule ADAP Regulates Dendritic Development of Hippocampal Neurons.Frontiers in molecular neuroscience · 2016Article
- SPARC triggers a cell-autonomous program of synapse elimination.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The serine/threonine kinase Ndr2 controls integrin trafficking and integrin-dependent neurite growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- ECM receptors in neuronal structure, synaptic plasticity, and behavior.Progress in brain research · 2014Review
- Differences between synaptic plasticity thresholds result in new timing rules for maximizing long-term potentiation.Neuropharmacology · 2013Review
- Immunoexcitatory mechanisms in glioma proliferation, invasion and occasional metastasis.Surgical neurology international · 2013Article
- Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- TSPAN7: A new player in excitatory synapse maturation and function.Bioarchitecture · 2012Article
- Integrins as receptor targets for neurological disorders.Pharmacology & therapeutics · 2012Review
- Synaptic evidence for the efficacy of spaced learning.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- AMPA receptors promote perivascular glioma invasion via beta1 integrin-dependent adhesion to the extracellular matrix.Neuro-oncology · 2009Article
- Integrin regulation of cytoplasmic calcium in excitatory neurons depends upon glutamate receptors and release from intracellular stores.Molecular and cellular neurosciences · 2008Article
- Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines.Brain research · 2007Article
- Restoration of long-term potentiation in middle-aged hippocampus after induction of brain-derived neurotrophic factor.Journal of neurophysiology · 2006Article
- Integrins control dendritic spine plasticity in hippocampal neurons through NMDA receptor and Ca2+/calmodulin-dependent protein kinase II-mediated actin reorganization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Integrin proteins are critical for stabilization of hippocampal long-term potentiation but the mechanisms by which integrin activities are involved in synaptic transmission are not known. The present study tested whether activation of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionate (AMPA) class glutamate receptors increases surface expression of alpha5beta1 integrin implicated in synaptic potentiation. Surface protein biotinylation assays demonstrated that AMPA treatment of COS7 cells expressing GluR1 homomeric AMPA receptors increased membrane insertion and steady-state surface levels of alpha5 and beta1 subunits. Treated cells exhibited increased adhesion to fibronectin- and anti-alpha5-coated substrates and tyrosine kinase signaling elicited by fibronectin-substrate adhesion, as expected if new surface receptors are functional. Increased surface expression did not occur in calcium-free medium and was blocked by the protein kinase C inhibitor chelerythrine chloride and the exocytosis inhibitor brefeldin A. AMPA treatment similarly increased alpha5 and beta1 surface expression in dissociated neurons and cultured hippocampal slices. In both neuronal preparations AMPA-induced integrin trafficking was blocked by combined antagonism of NMDA receptor and L-type voltage-sensitive calcium channel activities but was not induced by NMDA treatment alone. These results provide the first evidence that glutamate receptor activation increases integrin surface expression and function, and suggest a novel mechanism by which synaptic activity can engage a volley of new integrin signaling in coordination with, and probably involved in, stabilization of synaptic potentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.