Trial reportIntensive care medicine2005
Changes in acid-base balance following bolus infusion of 20% albumin solution in humans.
Trial report in Intensive care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- The Acid-Base Effects of Albumin in Sepsis: Reconciling the Stewart Physicochemical Approach with the Traditional Buffer-Base Paradigm.Journal of clinical medicine · 2026Review
- The Physiology, Pathophysiology, and Clinical Implications of Fluid Resuscitation in Critically Ill Patients.Cureus · 2026Review
- Article
- Understanding buffering of metabolic acidosis in critical illness.Intensive care medicine · 2024Article
- The Impact of Intravenous Fluid Therapy on Acid-Base Status of Critically Ill Adults: A Stewart Approach-Based Perspective.International journal of nephrology and renovascular disease · 2020Review
- Effects of crystalloid, hyper-oncotic albumin, and iso-oncotic albumin on lung and kidney damage in experimental acute lung injury.Respiratory research · 2019Article
- Effects of a rapid infusion of 20% human serum albumin solution on acid-base status and electrolytes in critically ill patients.Intensive care medicine · 2016Article
- Role of acidic pH of intravenous fluids in subsequent development of metabolic acidosis- may not be what it seems.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2014Article
- Blood viscosity modulates tissue perfusion: sometimes and somewhere.Transfusion alternatives in transfusion medicine : TATM · 2008Article
- Clinical Significance of Strong Ion Gap: between ICU and Hemodialysis Patients with Metabolic Acidosis.Electrolyte & blood pressure : E & BP · 2007Article
- Causes of metabolic acidosis in canine hemorrhagic shock: role of unmeasured ions.Critical care (London, England) · 2007Article
- [Stewart's acid-base approach].Wiener klinische Wochenschrift · 2007Review
- [Paradigm change due to the Stewart model of acid-base equilibrium? We must not re-learn but continue learning!].Wiener klinische Wochenschrift · 2007Article
- Comment on "Changes in acid-base balance following bolus infusion of 20% albumin solution in humans" by Bruegger et al.Intensive care medicine · 2006Article
- Comment on "Changes in acid-base balance following bolus infusion of 20% albumin solution in humans" by Bruegger et al.Intensive care medicine · 2006Article
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate changes in acid-base balance following bolus infusions of a 20% albumin solution. DESIGN AND
settingRandomized prospective study in a university hospital. PATIENTS AND
participantsTwo groups of eight patients each undergoing gynecological surgery.
interventionsPatients were randomly assigned to receive either 0.9% saline or lactated Ringer's solution. At the end of surgery two boluses of 0.5 g/kg body weight of a 20% albumin solution were administered. Arterial blood gases, electrolytes, and total protein were measured. The strong ion difference and the amount of weak plasma acid were calculated. pH and titratable acidity of the 20% albumin solution were determined. MEASUREMENTS AND
resultsThe infusion of a 20% albumin solution resulted in a significant decrease in pH from 7.284 to 7.262 in the saline group and from 7.422 to 7.394 in the Ringer's group. In both groups the 20% albumin solution caused an increase in strong ion difference and an increase in the amount of weak plasma acid. The observed changes in serum bicarbonate concentration were in good agreement with the changes in strong ion difference and the amount of weak plasma acid. The 20% albumin solution possessed a pH of 6.95 and a titratable acidity of 8.5 [corrected] mEq/l.
conclusionsAccording to the Stewart approach, the observed changes in acid-base balance are the net result of the two opposing effects of the strong ion difference and the amount of weak plasma acid. Alternatively, the acidifying effect of the 20% albumin solution may stem from the titratable acid content of the solution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.