ArticleGenome research2005
An atlas of human gene expression from massively parallel signature sequencing (MPSS).
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed.
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- Characterization and analysis of the transcriptome in Gymnocypris selincuoensis on the Qinghai-Tibetan Plateau using single-molecule long-read sequencing and RNA-seq.DNA research : an international journal for rapid publication of reports on genes and genomes · 2019Article
- Reviving the Transcriptome Studies: An Insight Into the Emergence of Single-Molecule Transcriptome Sequencing.Frontiers in genetics · 2019Review
- Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome.Frontiers in immunology · 2018Article
- SV-BR-1-GM, a Clinically Effective GM-CSF-Secreting Breast Cancer Cell Line, Expresses an Immune Signature and Directly Activates CD4Frontiers in immunology · 2018Article
- Comparative study of gastric cancer and chronic gastritis via network analysis.Gastroenterology and hepatology from bed to bench · 2018Article
- Comprehensive Analysis of Tissue-wide Gene Expression and Phenotype Data Reveals Tissues Affected in Rare Genetic Disorders.Cell systems · 2017Article
- In vivo mapping of tissue- and subcellular-specific proteomes inScience advances · 2017Article
- Analysis of gene expression in the nervous system identifies key genes and novel candidates for health and disease.Neurogenetics · 2017Article
- De novo transcriptome analyses of host-fungal interactions in oil palm (Elaeis guineensis Jacq.).BMC genomics · 2016Article
- A common molecular signature in ASD gene expression: following Root 66 to autism.Translational psychiatry · 2016Review
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- MGFM: a novel tool for detection of tissue and cell specific marker genes from microarray gene expression data.BMC genomics · 2015Article
- A Genome-Wide Landscape of Retrocopies in Primate Genomes.Genome biology and evolution · 2015Article
- Human protein interaction networks across tissues and diseases.Frontiers in genetics · 2015Review
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25 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used massively parallel signature sequencing (MPSS) to sample the transcriptomes of 32 normal human tissues to an unprecedented depth, thus documenting the patterns of expression of almost 20,000 genes with high sensitivity and specificity. The data confirm the widely held belief that differences in gene expression between cell and tissue types are largely determined by transcripts derived from a limited number of tissue-specific genes, rather than by combinations of more promiscuously expressed genes. Expression of a little more than half of all known human genes seems to account for both the common requirements and the specific functions of the tissues sampled. A classification of tissues based on patterns of gene expression largely reproduces classifications based on anatomical and biochemical properties. The unbiased sampling of the human transcriptome achieved by MPSS supports the idea that most human genes have been mapped, if not functionally characterized. This data set should prove useful for the identification of tissue-specific genes, for the study of global changes induced by pathological conditions, and for the definition of a minimal set of genes necessary for basic cell maintenance. The data are available on the Web at http://mpss.licr.org and http://sgb.lynxgen.com.
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