ArticleThe Journal of cell biology2005
Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- ATPase N-ethylmaleimide-sensitive factor mediated calcium dependent fusion pore closure and endocytosis.Communications biology · 2026Article
- α-galactosidase A deficiency promotes von Willebrand factor secretion in models of Fabry disease.Kidney international · 2019Article
- Redox Signaling in Neurotransmission and Cognition During Aging.Antioxidants & redox signaling · 2018Review
- Thrombotic Regulation From the Endothelial Cell Perspectives.Arteriosclerosis, thrombosis, and vascular biology · 2018Review
- Disruption of protein complexes containing protein phosphatase 2B and Munc18c reduces the secretion of von Willebrand factor from endothelial cells.Journal of thrombosis and haemostasis : JTH · 2017Article
- Depressive-Like Behaviors Are Regulated by NOX1/NADPH Oxidase by Redox Modification of NMDA Receptor 1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Mechanical Compression Effects on the Secretion of vWF and IL-8 by Cultured Human Vein Endothelium.PloS one · 2017Article
- ROS-activated calcium signaling mechanisms regulating endothelial barrier function.Cell calcium · 2016Review
- Nitric oxide synthase promotes distension-induced tracheal venular leukocyte adherence.PloS one · 2014Article
- Intra-membrane signaling between the voltage-gated Ca2+-channel and cysteine residues of syntaxin 1A coordinates synchronous release.Scientific reports · 2013Article
- Using the BITOLA system to identify candidate genes for Parkinson's disease.Bosnian journal of basic medical sciences · 2011Article
- Von Willebrand factor and oxidative stress parameters in acute coronary syndromes.Oxidative medicine and cellular longevity · 2011Article
- Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries.Circulation research · 2010Article
- Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells.The Journal of biological chemistry · 2010Article
- Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Epigallocatechin gallate inhibits endothelial exocytosis.Biological chemistry · 2008Article
- Nitric oxide regulation of protein trafficking in the cardiovascular system.Cardiovascular research · 2007Review
- Cellular functions of NSF: not just SNAPs and SNAREs.FEBS letters · 2007Review
- Donut-like topology of synaptic vesicles with a central cluster of mitochondria wrapped into membrane protrusions: a novel structure-function module of the adult calyx of Held.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Although an excess of reactive oxygen species (ROS) can damage the vasculature, low concentrations of ROS mediate intracellular signal transduction pathways. We hypothesized that hydrogen peroxide plays a beneficial role in the vasculature by inhibiting endothelial exocytosis that would otherwise induce vascular inflammation and thrombosis. We now show that endogenous H(2)O(2) inhibits thrombin-induced exocytosis of granules from endothelial cells. H(2)O(2) regulates exocytosis by inhibiting N-ethylmaleimide sensitive factor (NSF), a protein that regulates membrane fusion events necessary for exocytosis. H(2)O(2) decreases the ability of NSF to hydrolyze adenosine triphosphate and to disassemble the soluble NSF attachment protein receptor complex. Mutation of NSF cysteine residue C264T eliminates the sensitivity of NSF to H(2)O(2), suggesting that this cysteine residue is a redox sensor for NSF. Increasing endogenous H(2)O(2) levels in mice decreases exocytosis and platelet rolling on venules in vivo. By inhibiting endothelial cell exocytosis, endogenous H(2)O(2) may protect the vasculature from inflammation and thrombosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.