ArticleThe Journal of experimental medicine2005
BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- Prospective Phase II Trial of Montelukast to Treat Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation and Investigation into Bronchiolitis Obliterans Syndrome Pathogenesis.Transplantation and cellular therapy · 2022Trial
- Fluticasone, Azithromycin, and Montelukast Treatment for New-Onset Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2016Trial
- Structure-based identification of compounds with potential as selective BLT1 antagonists.Scientific reports · 2025Article
- Cutaneous Exposure to Arsenicals Is Associated with Development of Constrictive Bronchiolitis in Mice.American journal of respiratory cell and molecular biology · 2023Article
- Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators.Frontiers in immunology · 2021Review
- The role of the LTBSeminars in immunology · 2017Review
- The yin and yang of leukotriene BSeminars in immunology · 2017Review
- Importance of the leukotriene B4-BLT1 and LTB4-BLT2 pathways in asthma.Seminars in immunology · 2017Review
- Spectrum of T-lymphocyte activities regulating allergic lung inflammation.Immunological reviews · 2017Review
- How I treat bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation.Blood · 2017Review
- Systemic leukotriene BThe Journal of physiology · 2016Article
- Expression of leukotriene B₄ receptor-1 on CD8⁺ T cells is required for their migration into tumors to elicit effective antitumor immunity.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- ICOS-expressing lymphocytes promote resolution of CD8-mediated lung injury in a mouse model of lung rejection.PloS one · 2013Article
- Proinflammatory and immunoregulatory roles of eicosanoids in T cells.Frontiers in immunology · 2013Article
- Enhanced Tim3 activity improves survival after influenza infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation.Journal of leukocyte biology · 2012Review
- Diagnosis and treatment of pulmonary chronic GVHD: report from the consensus conference on clinical practice in chronic GVHD.Bone marrow transplantation · 2011Review
- Fluticasone, azithromycin and montelukast therapy in reducing corticosteroid exposure in bronchiolitis obliterans syndrome after allogeneic hematopoietic SCT: a case series of eight patients.Bone marrow transplantation · 2011Article
- Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells.American journal of respiratory cell and molecular biology · 2011Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Leukotriene B4 is a lipid mediator that recently has been shown to have potent chemotactic activity for effector T lymphocytes mediated through its receptor, BLT1. Here, we developed a novel murine model of acute lung rejection to demonstrate that BLT1 controls effector CD8+ T cell trafficking into the lung and that disruption of BLT1 signaling in CD8+ T cells reduces lung inflammation and mortality in the model. In addition, we used BLT1-deficient mice and a BLT1 antagonist in two tracheal transplant models of lung transplantation to demonstrate the importance of BLT1 for the recruitment of T cells into tracheal allografts. We also show that BLT1-mediated CD8+ T cell recruitment plays an important role in the development of airway fibroproliferation and obliteration. Finally, in human studies of lung transplant recipients, we found that BLT1 is up-regulated on T lymphocytes isolated from the airways of patients with obliterative bronchiolitis. These data demonstrate that BLT1 contributes to the development of lung rejection and obliterative bronchiolitis by mediating effector T lymphocyte trafficking into the lung. This is the first report that describes a pathologic role for BLT1-mediated T lymphocyte recruitment in disease and identifies BLT1 as a potential therapeutic target after lung transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.