ArticleThe Journal of experimental medicine2005
Restricted MHC-peptide repertoire predisposes to autoimmunity.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Investigating conjunctival immune pathways in Sjögren and non-Sjögren disease associated dry eye.The ocular surface · 2026Article
- Article
- The Limitation of HLA Diversity as a Risk Factor for Pediatric-Onset Autoimmune Rheumatic Disease.Journal of clinical medicine · 2025Article
- Suppression of melanoma by mice lacking MHC-II: Mechanisms and implications for cancer immunotherapy.The Journal of experimental medicine · 2024Article
- Lymph Node Stromal Cell-Intrinsic MHC Class II Expression Promotes MHC Class I-Restricted CD8 T Cell Lineage Conversion to Regulatory CD4 T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- MHC-II alleles shape the CDR3 repertoires of conventional and regulatory naïve CD4Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Peptide presentation by HLA-DQ molecules is associated with the development of immune tolerance.PeerJ · 2018Article
- Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob.Immunity · 2017Article
- Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA.Oncoimmunology · 2016Article
- Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for Allotransplantation.Frontiers in immunology · 2016Review
- T-cell receptor gene therapy--ready to go viral?Molecular oncology · 2015Review
- Crossreactive αβ T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection.Immunity · 2015Article
- MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity.Frontiers in immunology · 2013Review
- Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function.Immunological reviews · 2012Review
- Article
- On the logic of restrictive recognition of peptide by the T-cell antigen receptor.Immunologic research · 2011Article
- Why rethink the structure-function relationships regulating TCR behavior?Current trends in immunology · 2009Article
- Thymic selection stifles TCR reactivity with the main chain structure of MHC and forces interactions with the peptide side chains.Molecular immunology · 2008Review
- Development of CD4+ T cells expressing a nominally MHC class I-restricted T cell receptor by two different mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
MHC molecules associated with autoimmunity possess known structural features that limit the repertoire of peptides that they can present. Such limitation gives a selective advantage to TCRs that rely on interaction with the MHC itself, rather than with the peptide residues. At the same time, negative selection is impaired because of the lack of negatively selecting peptide ligands. The combination of these factors may predispose to autoimmunity. We found that mice with an MHC class II-peptide repertoire reduced to a single complex demonstrated various autoimmune reactions. Transgenic mice bearing a TCR (MM14.4) cloned from such a mouse developed severe autoimmune dermatitis. Although MM14.4 originated from a CD4+ T cell, dermatitis was mediated by CD8+ T cells. It was established that MM14.4+ is a highly promiscuous TCR with dual MHC class I/MHC class II restriction. Furthermore, mice with a limited MHC-peptide repertoire selected elevated numbers of TCRs with dual MHC class I/MHC class II restriction, a likely source of autoreactivity. Our findings may help to explain the link between MHC class I responses that are involved in major autoimmune diseases and the well-established genetic linkage of these diseases with MHC class II.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.