ArticleGenetics2005
Two quantitative trait loci for prepulse inhibition of startle identified on mouse chromosome 16 using chromosome substitution strains.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior.Scientific reports · 2021Article
- A Cross-Species Systems Genetics Analysis Links APBB1IP as a Candidate for Schizophrenia and Prepulse Inhibition.Frontiers in behavioral neuroscience · 2019Article
- Acoustic startle modification as a tool for evaluating auditory function of the mouse: Progress, pitfalls, and potential.Neuroscience and biobehavioral reviews · 2017Review
- Integration of genome-wide association and extant brain expression QTL identifies candidate genes influencing prepulse inhibition in inbred F1 mice.Genes, brain, and behavior · 2016Article
- Forward genetic approaches to understanding complex behaviors.Current topics in behavioral neurosciences · 2012Review
- Mapping quantitative traits and strategies to find quantitative trait genes.Methods (San Diego, Calif.) · 2011Review
- Fine mapping of QTL for prepulse inhibition in LG/J and SM/J mice using F(2) and advanced intercross lines.Genes, brain, and behavior · 2010Article
- QTL analysis of measures of mouse home-cage activity using B6/MSM consomic strains.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.PLoS pathogens · 2010Article
- Genomic survey of prepulse inhibition in mouse chromosome substitution strains.Genes, brain, and behavior · 2009Article
- Article
- Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: suggestive linkage to 3q13.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Article
- Short-term selective breeding for high and low prepulse inhibition of the acoustic startle response; pharmacological characterization and QTL mapping in the selected lines.Pharmacology, biochemistry, and behavior · 2008Article
- The evolution of drug development in schizophrenia: past issues and future opportunities.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008Review
- Neurophysiological endophenotypes across bipolar and schizophrenia psychosis.Schizophrenia bulletin · 2008Review
- Mouse consomic strains: exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies.Genome research · 2008Article
- A novel rat strain with enhanced sensitivity to the effects of dopamine agonists on startle gating.Pharmacology, biochemistry, and behavior · 2008Article
- Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype.PLoS biology · 2007Article
- Strain differences in the disruption of prepulse inhibition of startle after systemic and intra-accumbens amphetamine administration.Pharmacology, biochemistry, and behavior · 2007Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 1 country.
Funding
Abstract
Prepulse inhibition (PPI) of acoustic startle is a genetically complex quantitative phenotype of considerable medical interest due to its impairment in psychiatric disorders such as schizophrenia. To identify quantitative trait loci (QTL) involved in mouse PPI, we studied mouse chromosome substitution strains (CSS) that each carry a homologous chromosome pair from the A/J inbred strain on a host C57BL/6J inbred strain background. We determined that the chromosome 16 substitution strain has elevated PPI compared to C57BL/6J (P = 1.6 x 10(-11)), indicating that chromosome 16 carries one or more PPI genes. QTL mapping using 87 F(2) intercross progeny identified two significant chromosome 16 loci with LODs of 3.9 and 4.7 (significance threshold LOD is 2.3). The QTL were each highly significant independently and do not appear to interact. Sequence variation between B6 and A/J was used to identify strong candidate genes in the QTL regions, some of which have known neuronal functions. In conclusion, we used mouse CSS to rapidly and efficiently identify two significant QTL for PPI on mouse chromosome 16. The regions contain a limited number of strong biological candidate genes that are potential risk genes for psychiatric disorders in which patients have PPI impairments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.