Evidence map›Paper›PMID 15998452›Full record

ArticleGenome biology2005

Genomic analysis of heat-shock factor targets in Drosophila.

Ian Birch-Machin, Shan Gao, David Huen, Richard McGirr, Robert A H White, Steven Russell

Abstract readComparative Study
In one paragraph

Article in Genome biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Tailoring of Proteostasis Networks with Heat Shock Factors.Cold Spring Harbor perspectives in biology · 2019
    Review
  10. Article
  11. Roles of heat shock factor 1 beyond the heat shock response.Cellular and molecular life sciences : CMLS · 2018
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ian Birch-MachinDepartment of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK. ib107@cam.ac.uk
Shan Gao
David Huen
Richard McGirr
Robert A H White
Steven Russell

Funding

Biotechnology and Biological Sciences Research Council G18877
6 · The paper itself

Abstract

We have used a chromatin immunoprecipitation-microarray (ChIP-array) approach to investigate the in vivo targets of heat-shock factor (Hsf) in Drosophila embryos. We show that this method identifies Hsf target sites with high fidelity and resolution. Using cDNA arrays in a genomic search for Hsf targets, we identified 141 genes with highly significant ChIP enrichment. This study firmly establishes the potential of ChIP-array for whole-genome transcription factor target mapping in vivo using intact whole organisms.

Indexed as

GenomicsAnimalsBase SequenceDNA PrimersDrosophila melanogasterDrosophila ProteinsEmbryo, NonmammalianHeat-Shock ProteinsOligonucleotide Array Sequence AnalysisPolymerase Chain ReactionSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription, GeneticDNA PrimersDrosophila ProteinsHeat-Shock ProteinsSaccharomyces cerevisiae Proteins

Identifiers

PMID15998452
PMCPMC1175994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.