ArticleBritish journal of pharmacology2005
Vascular effects of anandamide and N-acylvanillylamines in the human forearm and skin microcirculation.
Article in British journal of pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
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- Identification of Potential Metabolic Markers of Hypertension in Chinese Children.International journal of hypertension · 2021Article
- Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Review
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- The endocannabinoid anandamide causes endothelium-dependent vasorelaxation in human mesenteric arteries.Pharmacological research · 2016Article
- TRP channel cannabinoid receptors in skin sensation, homeostasis, and inflammation.ACS chemical neuroscience · 2014Review
- Vascular targets for cannabinoids: animal and human studies.British journal of pharmacology · 2014Review
- Effects of exercise stress on the endocannabinoid system in humans under field conditions.European journal of applied physiology · 2012Article
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- Evaluation of influence of acupuncture and electro-acupuncture for blood perfusion of stomach by laser Doppler blood perfusion imaging.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Excitation of cutaneous C nociceptors by intraplantar administration of anandamide.Brain research · 2009Article
- Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.British journal of pharmacology · 2009Article
- Virodhamine relaxes the human pulmonary artery through the endothelial cannabinoid receptor and indirectly through a COX product.British journal of pharmacology · 2008Article
- 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors.British journal of pharmacology · 2008Article
- An evaluation of the effect of a gastric ischemia-reperfusion model with laser Doppler blood perfusion imaging.Lasers in medical science · 2006Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endocannabinoid anandamide is an emerging potential signalling molecule in the cardiovascular system. Anandamide causes vasodilatation, bradycardia and hypotension in animals and has been implicated in the pathophysiology of endotoxic, haemorrhagic and cardiogenic shock, but its vascular effects have not been studied in man. Human forearm blood flow and skin microcirculatory flow were recorded using venous occlusion plethysmography and laser-Doppler perfusion imaging (LDPI), respectively. Each test drug was infused into the brachial artery or applied topically on the skin followed by a standardized pin-prick to disrupt the epidermal barrier. Anandamide failed to affect forearm blood flow when administered intra-arterially at infusion rates of 0.3-300 nmol min(-1). The highest infusion rate led to an anandamide concentration of approximately 1 microM in venous blood as measured by mass spectrometry. Dermal application of anandamide significantly increased skin microcirculatory flow and coapplication of the transient receptor potential vanilloid 1 (TRPV1) antagonist capsazepine inhibited this effect. The TRPV1 agonists capsaicin, olvanil and arvanil all induced concentration-dependent increases in skin blood flow and burning pain when administered dermally. Coapplication of capsazepine inhibited blood flow and pain responses to all three TRPV1 agonists. This study shows that locally applied anandamide is a vasodilator in the human skin microcirculation. The results are consistent with this lipid being an activator of TRPV1 on primary sensory nerves, but do not support a role for anandamide as a circulating vasoactive hormone in the human forearm vascular bed.
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