ArticleClinical and experimental immunology2005
Bacterial lipopolysaccharide both renders resistant mice susceptible to mercury-induced autoimmunity and exacerbates such autoimmunity in susceptible mice.
Article in Clinical and experimental immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Drug-Induced Membranous Nephropathy: Piecing Together Clues to Understand Disease Mechanisms.Journal of the American Society of Nephrology : JASN · 2025Review
- Mechanisms of Immunotoxicity: Stressors and Evaluators.International journal of molecular sciences · 2021Review
- An Animal Model Using Metallic Ions to Produce Autoimmune Nephritis.Journal of immunology research · 2015Article
- Low-dose mercury heightens early innate response to coxsackievirus infection in female mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Review
- Prevention or acceleration of type 1 diabetes by viruses.Cellular and molecular life sciences : CMLS · 2013Review
- Immunomodulatory effects of environmental endocrine disrupting chemicals.The Kaohsiung journal of medical sciences · 2012Review
- Differential immunotoxic effects of inorganic and organic mercury species in vitro.Toxicology letters · 2010Article
- Mercury induces an unopposed inflammatory response in human peripheral blood mononuclear cells in vitro.Environmental health perspectives · 2009Article
- Immunomodulation by mercuric chloride in vitro: application of different cell activation pathways.Clinical and experimental immunology · 2007Article
- Mercury-induced cognitive impairment in metallothionein-1/2 null mice.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The initiation and severity of systemic autoimmune diseases are influenced by a variety of genetic and environmental factors, in particular bacterial infections and products. Here, we have employed bacterial lipopolysaccharide (LPS), which non-specifically activates the immune system, to explore the involvement of innate immunity in mercury-induced autoimmunity in mice. Following treatment of mouse strains resistant [DBA/2 (H-2(d))] or susceptible [SJL(H-2(s))] to such autoimmunity with mercuric chloride and/or LPS or with physiological saline alone (control), their immune/autoimmune responses were monitored. Resistant DBA/2 mice were rendered susceptible to mercury-induced autoimmunity by co-administration of LPS, exhibiting pronounced increases in the synthesis of IgG1 and IgE, high titres of IgG1 deposits in the kidneys and elevated circulating levels of IgG1 antibodies of different specificities. Furthermore, the percentages of the T cells isolated from the spleens of DBA/2 mice exposed to both mercury and LPS that produced pro-inflammatory cytokines were markedly increased by in vitro stimulation with phorbol myristate acetate (PMA) and ionomycin, which was not the case for splenic T cells isolated from mice receiving mercuric chloride, LPS or saline alone. In addition, exposure of susceptible SJL mice to mercury in combination with LPS aggravated the characteristic features of mercury-induced autoimmunity, including increased synthesis of IgG1 and IgE, the production of IgG1 anti-nucleolar antibodies (ANolA) and the formation of renal deposits of IgG1. In summary, our findings indicate that activation of the innate immune system plays a key role in both the induction and severity of chemically induced autoimmunity.
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