ArticleClinical and experimental immunology2005
Strain-specific differences in perivascular inflammation in lungs in two murine models of allergic airway inflammation.
Article in Clinical and experimental immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 56 citations in OpenAlex.
- Treatment of allergic eosinophilic asthma through engineered IL-5-anchored chimeric antigen receptor T cells.Cell discovery · 2022Article
- Lesions in the lungs of fatal corona virus disease Covid-19.Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2021Review
- A Synthetic Curcuminoid Analogue, 2,6-Bis-4-(Hydroxyl-3-Methoxybenzylidine)-Cyclohexanone (BHMC) Ameliorates Acute Airway Inflammation of Allergic Asthma in Ovalbumin-Sensitized Mice.Mediators of inflammation · 2021Article
- Bcl6 and Blimp1 reciprocally regulate ST2The Journal of allergy and clinical immunology · 2020Article
- Lung-Infiltrating Foxp3Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Angiotensin-(1-7) attenuates airway remodelling and hyperresponsiveness in a model of chronic allergic lung inflammation.British journal of pharmacology · 2015Article
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- Inflammatory priming predisposes mice to age-related retinal degeneration.The Journal of clinical investigation · 2012Article
- Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study.Clinical and experimental immunology · 2011Article
- Direct leukocyte migration across pulmonary arterioles and venules into the perivascular interstitium of murine lungs during bleomycin injury and repair.The American journal of pathology · 2011Article
- Mast cell progenitor trafficking and maturation.Advances in experimental medicine and biology · 2011Review
- Toll-like receptor 4 deficiency increases disease and mortality after mouse hepatitis virus type 1 infection of susceptible C3H mice.Journal of virology · 2009Article
- Lipopolysaccharide induced inflammation in the perivascular space in lungs.Journal of occupational medicine and toxicology (London, England) · 2008Article
- Coagulation factor Xa modulates airway remodeling in a murine model of asthma.American journal of respiratory and critical care medicine · 2007Article
- Article
- Host genetics of Bordetella pertussis infection in mice: significance of Toll-like receptor 4 in genetic susceptibility and pathobiology.Infection and immunity · 2006Article
- Differential in vivo effects of whole cigarette smoke exposure versus cigarette smoke extract on mouse ciliated tracheal epithelium.Experimental lung researchArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histological data show perivascular recruitment of inflammatory cells in lung inflammation. However, the process of perivascular inflammation is yet-to-be characterized in any systematic manner at cell and molecular levels. Therefore, we investigated impact of genetic background on perivascular inflammation in acute or chronic airway inflammation in different strains of mice. Further, to address molecular mechanisms of perivascular inflammation, we examined immunohistochemical expression of vascular adhesion protein-1 (VAP-1) in chronic airway inflammation. Histological scoring revealed time and strain specific differences in perivascular recruitment of inflammatory cells in chronic and acute airway inflammation (P < 0.05). The data show that A/J strain is significantly more susceptible for perivascular inflammation followed by BALB/c and C57BL/6, while C3H/HeJ strain showed no perivascular accumulation of inflammatory cells. Of the two strains examined for perivascular inflammation in acute airway inflammation, BALB/c showed more accumulation of inflammatory cells compared to C57BL/c. VAP-1 expression occurred in the endothelium of pulmonary arteries but not in alveolar septa or airways in the control as well as challenged mice. In the inflamed lungs from A/J mice, the VAP-1 staining in pulmonary arteries was more intense compared to the other strains. VAP-1 staining was generally observed throughout the pulmonary arterial wall in chronic lung inflammation. These data show that periarterial inflammation is influenced by the genetic background, and may be partially regulated by VAP-1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.