ReviewClinical and experimental immunology2005
Off balance: T-cells in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Review in Clinical and experimental immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
- Rapamycin Modulates the Polarisation of CD4+ T Cells Towards TJournal of clinical medicine · 2025Article
- Immune Cells Profiling in ANCA-Associated Vasculitis Patients-Relation to Disease Activity.Cells · 2021Article
- Aging in Primary Systemic Vasculitis: Implications for Diagnosis, Clinical Manifestations, and Management.Drugs & aging · 2019Review
- Regulatory B cells are numerically but not functionally deficient in anti-neutrophil cytoplasm antibody-associated vasculitis.Rheumatology (Oxford, England) · 2014Article
- Systemic lupus erythematosus associated with ANCA-associated vasculitis: an overlapping syndrome?Rheumatology international · 2012Review
- Progress in treatment of ANCA-associated vasculitis.Arthritis research & therapy · 2012Review
- Article
- ANCA-associated vasculitides-lessons from the adult literature.Pediatric nephrology (Berlin, Germany) · 2010Review
- A CD8+ T cell transcription signature predicts prognosis in autoimmune disease.Nature medicine · 2010Article
- Analysis of T-cell receptor usage in myeloperoxidase--antineutrophil cytoplasmic antibody-associated renal vasculitis.Clinical and experimental nephrology · 2010Article
- ANCA-associated vasculitis: from bench research to novel treatments.Nature reviews. Nephrology · 2009Review
- [Wegener's granulomatosis and microscopic polyangiitis].Zeitschrift fur Rheumatologie · 2009Review
- Imatinib mesylate, a new kid on the block for the treatment of anti-neutrophil cytoplasmic autoantibodies-associated vasculitis?Clinical and experimental immunology · 2008Article
- [T-large granular lymphocyte leukaemia. An important differential diagnosis to Felty's syndrome].Zeitschrift fur Rheumatologie · 2006Review
- Pathogenic role and clinical relevance of antineutrophil cytoplasmic antibodies in vasculitides.Current rheumatology reports · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is substantial evidence that T-cells are off balance in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Genetic risk factors may influence shaping of the TCR repertoire and regulatory control of T-cells in predisposed individuals. T-cells are found in inflammatory lesions. Vigorous Th1-type responses are seen in Wegener's granulomatosis and microscopic angiitis, whereas a Th2-type response predominates in Churg-Strauss syndrome. Oligoclonality and shortened telomers indicate antigen-driven clonal expansion and replicative senescence of T-cells in ANCA-associated vasculitides. Potent CD28(-) Th1-type cells displaying an effector-memory/late differentiated, senescent phenotype are expanded in peripheral blood and are found in granulomatous lesions in Wegener's granulomatosis. Differences in proliferative peripheral blood T-cell responses to the autoantigens proteinase 3 (PR3)- and myeloperoxidase (MPO) have not consistently been detected between patients with ANCA-associated vasculitides and healthy controls in vitro. To recognize an autoantigen, break tolerance, and maintain autoimmune disease T- and B-cells require particular triggers and lymphoid structures. There is preliminary evidence of lymphoid-like structures and possible maturation of autoreactive PR3-ANCA-specific B-cells in granulomatous lesions in Wegener's granulomatosis. Alteration of the T-cell response and anomalous autoantigen-presentation in lymphoid-structures could facilitate development of autoimmune disease in ANCA-associated vasculitides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.