ReviewEuropean archives of psychiatry and clinical neuroscience2005
Genetic models of schizophrenia and bipolar disorder: overlapping inheritance or discrete genotypes?
Review in European archives of psychiatry and clinical neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis.Schizophrenia research · 2008Pooled it
- Meta-analysis of 12 genomic studies in bipolar disorder.Journal of molecular neuroscience : MN · 2007Pooled it
- [Schizophrenia and depression].Der Nervenarzt · 2006Trial
- Understanding translational research in schizophrenia: A novel insight into animal models.Molecular biology reports · 2023Review
- The molecular genetics of hand preference revisited.Scientific reports · 2019Article
- Family History in Patients with Bipolar Disorder.Noro psikiyatri arsivi · 2016Article
- Expression of the G72/G30 gene in transgenic mice induces behavioral changes.Molecular psychiatry · 2014Article
- Association between FAT Gene and Schizophrenia in the Korean Population.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2013Article
- Comparisons of the tolerability and sensitivity of quetiapine-XR in the acute treatment of schizophrenia, bipolar mania, bipolar depression, major depressive disorder, and generalized anxiety disorder.The international journal of neuropsychopharmacology · 2011Review
- C677T Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism in Schizophrenia and Bipolar Disorder: An Association Study in Iranian Population.Iranian journal of psychiatry · 2011Article
- Construction and analysis of the protein-protein interaction networks for schizophrenia, bipolar disorder, and major depression.BMC bioinformatics · 2011Article
- Lack of association between MAGEL2 and schizophrenia and mood disorders in the Japanese population.Neuromolecular medicine · 2010Article
- Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.Molecular psychiatry · 2010Article
- The effect of the COMT val(158)met polymorphism on neural correlates of semantic verbal fluency.European archives of psychiatry and clinical neuroscience · 2009Article
- Common and rare variants of DAOA in bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2009Article
- Effect of the G72 (DAOA) putative risk haplotype on cognitive functions in healthy subjects.BMC psychiatry · 2009Article
- Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population.European archives of psychiatry and clinical neuroscience · 2009Article
- Elevated cerebrospinal fluid lactate concentrations in patients with bipolar disorder and schizophrenia: implications for the mitochondrial dysfunction hypothesis.Biological psychiatry · 2009Article
- Bipolar disorder and neurophysiologic mechanisms.Neuropsychiatric disease and treatment · 2008Article
- Systematic of psychiatric disorders between categorical and dimensional approaches: Kraepelin's dichotomy and beyond.European archives of psychiatry and clinical neuroscience · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia and affective disorder have been considered to be nosologically and etiologically distinct disorders. This postulate is challenged by progress in new biological research. Both disorders are strongly influenced by genetic factors; thus genetic research is a main contributor to this discussion. We review current evidence of the genetic relationship between schizophrenia and affective disorders, mainly bipolar disorder (the various genetic research methods have been particularly applied to bipolar disorder). Recent family and twin studies reveal a growing consistency in demonstrating cosegregation between both disorders which is difficult to detect with certainty given the low base rates. Systematic molecular genetic search for specific genes impacting on either disorder has now identified one gene which is apparently involved in both disorders (G72/G30); other candidate genes reveal some evidence to present as susceptibility genes with very modest effects for each of both disorders, although not consistently so (e. g., COMT, BDNF). There is room for speculation about other common susceptibility genes, given the overlap between candidate regions for schizophrenia and those for bipolar disorder emerging from linkage studies.
Indexed as
Identifiers
15995899What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.