ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2006
Sarcopenia in premenopausal and postmenopausal women with osteopenia, osteoporosis and normal bone mineral density.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 3 of them syntheses that pooled it.
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Who cites it
97 citing papers in PubMed, 3 syntheses or guidelines pooled it, 272 citations in OpenAlex.
- Prevalence of osteosarcopenia in postmenopausal women: a systematic review and meta-analysis.Journal of endocrinological investigation · 2026Pooled it
- Prevalence and risk factors of osteosarcopenia: a systematic review and meta-analysis.BMC geriatrics · 2023Pooled it
- Systematic Review: The Impact and Importance of Body Composition in Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2022Pooled it
- Effect of resistance training and chicken meat on muscle strength and mass and the gut microbiome of older women: A randomized controlled trial.Physiological reports · 2024Trial
- Effects of a dynamic combined training on impulse response for middle-aged and elderly patients with osteoporosis and knee osteoarthritis: a randomized control trial.Aging clinical and experimental research · 2021Trial
- Effects of Progressive Walking and Stair-Climbing Training Program on Muscle Size and Strength of the Lower Body in Untrained Older Adults.Journal of sports science & medicine · 2019Trial
- Stress urinary incontinence and sarcopenia in postmenopausal osteoporosis: the intersection of muscle loss and pelvic dysfunction.World journal of urology · 2026Article
- Association between appendicular skeletal muscle index and bone turnover markers and bone mineral density in postmenopausal osteoporotic women.Archives of osteoporosis · 2025Article
- The relationship between osteoporosis and sarcopenia parameters in postmenopausal women under 60 years of age: A cross-sectional study.Irish journal of medical science · 2025Article
- Prevalence and predictors of osteosarcopenia and relationship with physical functionality in rural and urban Indian women.Archives of osteoporosis · 2025Article
- Association between metabolic score for visceral fat index and BMI-adjusted skeletal muscle mass index in American adults.Lipids in health and disease · 2025Article
- Prevalence of Osteoporosis and Sarcopenia in Middle-Aged Subjects with Low Back Pain.The Indian journal of radiology & imaging · 2025Article
- Lipid peroxidation and sarcopenia: molecular mechanisms and potential therapeutic approaches.Frontiers in medicine · 2025Review
- The association between computed tomography-based osteosarcopenia and osteoporotic vertebral fractures: a longitudinal study.Journal of endocrinological investigation · 2025Article
- Comparison of bioelectrical impedance analysis and dual-energy X-ray absorptiometry for the diagnosis of sarcopenia in the older adults with metabolic syndrome: equipment-specific equation development.Aging clinical and experimental research · 2024Review
- Differences in sarcopenia indices in elderly Japanese women and their relationships with obesity classified according to waist circumference, BMI, and body fat percentage.Journal of physiological anthropology · 2024Article
- Investigation of outcome measures and anomalous lower extremity in osteoarthritis patients with Jumpstart nutrition® supplementation.Caspian journal of internal medicine · 2024Review
- Bisphosphonates attenuate age-related muscle decline in Caenorhabditis elegans.Journal of cachexia, sarcopenia and muscle · 2023Article
- Associations between body composition and cardiovascular disease risk in pre- and postmenopausal women.Journal of health, population, and nutrition · 2023Article
- Assessments of sarcopenia and its associated factors in community-dwelling middle-aged and older Chinese adults in Kelantan, Malaysia.Scientific reports · 2023Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Sarcopenia, the decline of muscle mass with age, causes impaired gait, disability and falls. It may therefore increase the risk of fracture for osteoporotic women. The aims of this study were to determine the prevalence of sarcopenia in osteopenic and osteoporotic women, and to determine if hormone replacement therapy (HRT), diet, or physical activity (PA) has a role in the prevention of sarcopenia. One hundred and thirty-one premenopausal and 82 postmenopausal (54 taking HRT) healthy women (17-77 years) volunteered for the study. Body composition was measured by dual X-ray absorptiometry (DXA). Sarcopenia was defined as a relative skeletal muscle index (RSMI) (appendicular skeletal muscle mass divided by height) below 5.45 kg/m2. Osteopenia was defined by a densitometric t-score for bone mineral density (BMD) (g/cm2) below -1.0 and osteoporosis by a t-score below -2.5. Nutrient intake was assessed using 3-day food records and physical activity (PA) was measured using the Baecke Physical Activity Questionnaire. Pearson chi-squared, independent t-tests, simple correlation and multiple regression were used to analyze the data. In premenopausal osteopenic women the prevalence of sarcopenia was 12.5%. In postmenopausal women it was 25% for those with osteopenia, and 50% for those with osteoporosis. PA was independently related to RSMI (beta=0.222, p=0.0001), but diet and HRT were not. After adjusting for PA, RSMI was not significantly related to BMD. These data suggest that the relationship between RSMI, BMD and risk of osteoporosis may largely be mediated through participation in PA. Sarcopenia screening simultaneous to BMD examinations by DXA, may be of value in identifying osteoporotic women with sarcopenia, a group that may be most in need of exercise interventions to increase muscle and BMD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.