ArticleBiophysical journal2005
How noise and coupling induce bursting action potentials in pancreatic {beta}-cells.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- A primer on modelling pancreatic islets: from models of coupled β-cells to multicellular islet models.Islets · 2023Review
- Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets.Cellular and molecular life sciences : CMLS · 2023Review
- Ion channel noise shapes the electrical activity of endocrine cells.PLoS computational biology · 2020Article
- A suppressor locus for MODY3-diabetes.Scientific reports · 2016Article
- Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise.PLoS computational biology · 2016Article
- The Beta Cell in Its Cluster: Stochastic Graphs of Beta Cell Connectivity in the Islets of Langerhans.PLoS computational biology · 2015Article
- Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics.Trends in endocrinology and metabolism: TEM · 2014Review
- Article
- How does evolution tune biological noise?Frontiers in genetics · 2014Review
- The fractal spatial distribution of pancreatic islets in three dimensions: a self-avoiding growth model.Physical biology · 2013Article
- The what and where of adding channel noise to the Hodgkin-Huxley equations.PLoS computational biology · 2011Review
- Formation of pancreatic islets involves coordinated expansion of small islets and fission of large interconnected islet-like structures.Biophysical journal · 2011Article
- Altered islet composition and disproportionate loss of large islets in patients with type 2 diabetes.PloS one · 2011Article
- A mathematical model of β-cells in an islet of Langerhans sensing a glucose gradient.HFSP journal · 2010Article
- Size distribution of mouse Langerhans islets.Biophysical journal · 2007Article
- Investigating the role of islet cytoarchitecture in its oscillation using a new beta-cell cluster model.PloS one · 2007Article
- Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unlike isolated beta-cells, which usually produce continuous spikes or fast and irregular bursts, electrically coupled beta-cells are apt to exhibit robust bursting action potentials. We consider the noise induced by thermal fluctuations as well as that by channel-gating stochasticity and examine its effects on the action potential behavior of the beta-cell model. It is observed numerically that such noise in general helps single cells to produce a variety of electrical activities. In addition, we also probe coupling via gap junctions between neighboring cells, with heterogeneity induced by noise, to find that it enhances regular bursts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.