ArticleBiophysical journal2005
Effect of input resistance voltage-dependency on DC estimate of membrane capacitance in cardiac myocytes.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The electrophysiology of ventricular cell pairs.Pflugers Archiv : European journal of physiology · 2025Review
- Optogenetic quantification of cardiac excitability and electrical coupling in intact hearts to explain cardiac arrhythmia initiation.Science advances · 2025Article
- Heterogeneity of ventricular action potentials in neonatal rat cardiomyocytes and methodological aspects of patch clamp measurements.Frontiers in physiology · 2025Article
- In silico analysis of ventricular action potential with a current-voltage-time representation: Thresholds, membrane resistance, repolarization reserve.Physiological reports · 2024Article
- Cobalt oxide nanoparticles induce oxidative stress and alter electromechanical function in rat ventricular myocytes.Particle and fibre toxicology · 2021Article
- Sub-microscopic analysis of t-tubule geometry in living cardiac ventricular myocytes using a shape-based analysis method.Journal of molecular and cellular cardiology · 2017Article
- Optogenetic versus Electrical Stimulation of Human Cardiomyocytes: Modeling Insights.Biophysical journal · 2015Article
- Titanium dioxide nanoparticles promote arrhythmias via a direct interaction with rat cardiac tissue.Particle and fibre toxicology · 2014Article
- Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing.Journal of molecular and cellular cardiology · 2014Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The measure of membrane capacitance (C(m)) in cardiac myocytes is of primary importance as an index of their size in physiological and pathological conditions, and for the understanding of their excitability. Although a plethora of very accurate methods has been developed to access C(m) value in single cells, cardiac electrophysiologists still use, in the majority of laboratories, classical direct current techniques as they have been established in the early days of cardiac cellular electrophysiology. These techniques are based on the assumption that cardiac membrane resistance (R(m)) is constant, or changes negligibly, in a narrow potential range around resting potential. Using patch-clamp whole-cell recordings, both in current-clamp and voltage-clamp conditions, and numerical simulations, we document here the voltage-dependency of R(m), up to -45% of its resting value for 10-mV hyperpolarization, in resting rat ventricular myocytes. We show how this dependency makes classical protocols to misestimate C(m) in a voltage-dependent manner (up to 20% errors), which can dramatically affect C(m)-based calculations on cell size and on intracellular ion dynamics. We develop a simple mechanistic model to fit experimental data and obtain voltage-independent estimates of C(m), and we show that accurate estimates can also be extrapolated from the classical approach.
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