ArticleJournal of medical genetics2005
Is the Ala12 variant of the PPARG gene an "unthrifty allele"?
Article in Journal of medical genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis.American journal of epidemiology · 2010 · on this mapPooled it
- Assessment of the Pro12Ala Polymorphism in the PPAR-γ2 Gene among Type 2 Diabetes Patients in a Nigerian Population.Journal of clinical medicine · 2018Article
- The Pro12Ala polymorphism in the PPAR-γ2 gene is not associated to obesity and type 2 diabetes mellitus in a Cameroonian population.BMC obesity · 2016Article
- Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia.European journal of human genetics : EJHG · 2013Article
- The TCF7L2 rs7903146 (T) allele is associated with type 2 diabetes in urban Ghana: a hospital-based case-control study.BMC medical genetics · 2013Article
- Amerindians show no association of PPAR-γ2 gene Ala12 allele and obesity: an "unthrifty" variant population genetics.Molecular biology reports · 2013Article
- Association of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy.Molecular vision · 2013Article
- Diverse evolutionary histories for beta-adrenoreceptor genes in humans.American journal of human genetics · 2009Article
- Better outcome of schizophrenia in India: a natural selection against severe forms?Schizophrenia bulletin · 2009Article
- The integration of lipid-sensing and anti-inflammatory effects: how the PPARs play a role in metabolic balance.Nuclear receptor · 2007Article
- Patterns of association between PPARgamma genetic variation and indices of adiposity and insulin action in African-Americans and whites: the CARDIA Study.Journal of molecular medicine (Berlin, Germany) · 2006Article
- Genetic epidemiology of type 2 diabetes and cardiovascular diseases in Africa.Progress in cardiovascular diseasesReview
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1 author.
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Abstract
backgroundThe thrifty genotype hypothesis proposes that genetic susceptibility to type 2 diabetes results from the positive selection of "thrifty" alleles in the past. A corollary of this hypothesis is that genetic variants protecting against the development of diabetes are "unthrifty" and thus subject to negative selection during human evolution.
methodsIt was assessed whether age estimates of the diabetes protective PPARG Ala12 allele indicate effects of natural selection. Based on published data from four populations, the date of origin of the diabetes protective PPARG Ala12 variant was estimated using both allele frequency and linkage disequilibrium (LD) with the C1431T single nucleotide polymorphism in exon 6 of the PPARG gene.
resultsThe best LD based estimate of the age of the Ala12 allele gave an average of approximately 32,000 years with a maximum upper bound of approximately 58,000 years. Assuming a population with a growth rate of r = 0.01 per generation, the frequency based estimate of the age of the Ala12 variant gave an average of approximately 27,000 years with a maximum upper bound of approximately 42,000 years. DISCUSSION: The similarity of both time estimates is consistent with selective equivalence of the diabetes protective PPARG Ala12 allele and the diabetes susceptible PPARG Pro12 allele.
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