ArticleJournal of virology2005
Comparison of the genetic recombination rates of human immunodeficiency virus type 1 in macrophages and T cells.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Estimates of HIV-1 within-host recombination rates across the whole genome.Virus evolution · 2025Article
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- Fifteen to twenty percent of HIV substitution mutations are associated with recombination.Journal of virology · 2014Article
- Identifying recombination hot spots in the HIV-1 genome.Journal of virology · 2014Article
- Host SAMHD1 protein promotes HIV-1 recombination in macrophages.The Journal of biological chemistry · 2014Article
- Longitudinal analysis of intra-host simian immunodeficiency virus recombination in varied tissues of the rhesus macaque model for neuroAIDS.The Journal of general virology · 2013Article
- Viral determinants of HIV-1 macrophage tropism.Viruses · 2011Review
- HIV-1 nucleocapsid protein increases strand transfer recombination by promoting dimeric G-quartet formation.The Journal of biological chemistry · 2011Article
- Evolution and recombination of genes encoding HIV-1 drug resistance and tropism during antiretroviral therapy.Virology · 2010Article
- Accurately measuring recombination between closely related HIV-1 genomes.PLoS computational biology · 2010Article
- A recombination hot spot in HIV-1 contains guanosine runs that can form a G-quartet structure and promote strand transfer in vitro.The Journal of biological chemistry · 2009Article
- The remarkable frequency of human immunodeficiency virus type 1 genetic recombination.Microbiology and molecular biology reviews : MMBR · 2009Review
- Mechanism analysis indicates that recombination events in HIV-1 initiate and complete over short distances, explaining why recombination frequencies are similar in different sections of the genome.Journal of molecular biology · 2009Article
- HIV-1 recombination: an experimental assay and a phylogenetic approach.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Extensive HIV-1 intra-host recombination is common in tissues with abnormal histopathology.PloS one · 2009Article
- Emergence of recombinant forms of HIV: dynamics and scaling.PLoS computational biology · 2007Article
- Contribution of recombination to the evolution of human immunodeficiency viruses expressing resistance to antiretroviral treatment.Journal of virology · 2007Article
- Influence of sequence identity and unique breakpoints on the frequency of intersubtype HIV-1 recombination.Retrovirology · 2006Article
- High frequency of genetic recombination is a common feature of primate lentivirus replication.Journal of virology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Human immunodeficiency virus type 1 (HIV-1) exhibits a high level of genetic variation generated by frequent mutation and genetic recombination during reverse transcription. We have measured HIV-1 recombination rates in T cells in one round of virus replication. It was recently proposed that HIV-1 recombines far more frequently in macrophages than in T cells. In an attempt to delineate the mechanisms that elevate recombination, we measured HIV-1 recombination rates in macrophages at three different marker distances. Surprisingly, the recombination rates were comparable in macrophages and in T cells. In addition, we observed similar recombination rates in two monocytic cell lines regardless of the differentiation status. These results indicate that HIV-1 undergoes similar numbers of recombination events when infecting macrophages and T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.