ArticleJournal of virology2005
Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Consequences of HIV infection in the bone marrow niche.Frontiers in immunology · 2023Review
- Molecular Modeling of Subtype-Specific Tat Protein Signatures to Predict Tat-TAR Interactions That May Be Involved in HIV-Associated Neurocognitive Disorders.Frontiers in microbiology · 2022Article
- Genetic variation and function of the HIV-1 Tat protein.Medical microbiology and immunology · 2019Review
- A Naturally Occurring Polymorphism in the HIV-1 Tat Basic Domain Inhibits Uptake by Bystander Cells and Leads to Reduced Neuroinflammation.Scientific reports · 2019Article
- A strategy for effective latent HIV reactivation using subtherapeutic drug doses.Scientific reports · 2017Article
- A mutant Tat protein inhibits infection of human cells by strains from diverse HIV-1 subtypes.Virology journal · 2017Article
- A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors.Nature genetics · 2017Article
- Article
- Stability of HIV-1 subtype B and C Tat is associated with variation in the carboxyl-terminal region.Virologica Sinica · 2016Article
- Molecular characterization of full-length Tat in HIV-1 subtypes B and C.Bioinformation · 2015Article
- Article
- Molecular and genetic characterization of natural HIV-1 Tat Exon-1 variants from North India and their functional implications.PloS one · 2014Article
- Roles and functions of HIV-1 Tat protein in the CNS: an overview.Virology journal · 2013Review
- tat Exon 1 exhibits functional diversity during HIV-1 subtype C primary infection.Journal of virology · 2013Article
- HMGA1 directly interacts with TAR to modulate basal and Tat-dependent HIV transcription.RNA biology · 2013Article
- Use of ATP analogs to inhibit HIV-1 transcription.Virology · 2012Article
- Mutual information analysis reveals coevolving residues in Tat that compensate for two distinct functions in HIV-1 gene expression.The Journal of biological chemistry · 2012Article
- Differential induction of rat neuronal excitotoxic cell death by human immunodeficiency virus type 1 clade B and C tat proteins.AIDS research and human retroviruses · 2011Article
- Article
- Structural and functional studies of CCAAT/enhancer binding sites within the human immunodeficiency virus type 1 subtype C LTR.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2010Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major group of human immunodeficiency virus type 1 (HIV-1) strains that comprise the current global pandemic have diversified during their worldwide spread into at least 10 distinct subtypes, or clades. Subtype C predominates in sub-Saharan Africa and is responsible for the majority of worldwide HIV-1 infections, subtype B predominates in North America and Europe, and subtype E is prevalent in Southeast Asia. Significant amino acid variations have been observed among the clade-specific Tat proteins. For the present study, we examined clade-specific interactions between Tat, transactivation-responsive (TAR) element, and P-TEFb proteins and how these interactions may modulate the efficiency of HIV-1 transcription. Clade-specific Tat proteins significantly modified viral gene expression. Tat proteins derived from HIV-1 clades C and E were strong transactivators of long terminal repeat (LTR) activity; Tat E also had a longer half-life than the other Tat proteins and interacted more efficiently with the stem-loop TAR element. Chimeric Tat proteins harboring the Tat E activation domain were strong transactivators of LTR expression. While Tat B, C, and E were able to rescue a Tat-defective HIV-1 proviral clone, Tat E was significantly more efficient at rescue than Tat C, possibly due to the relative stability of the Tat protein. Swapping the activation domains of Tat B, C, and E identified the cyclin T1 association domain as a critical determinant of the transactivation efficiency and of Tat-defective HIV-1 provirus rescue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.