ArticleBlood2005
Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN.
Article in Blood, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Interaction Between microRNAs and Myeloid-Derived Suppressor Cells in Tumor Microenvironment.Frontiers in immunology · 2022Review
- Calcium Phosphate Coating Prepared by Microarc Oxidation AffectsMaterials (Basel, Switzerland) · 2020Article
- Molecular control of PtdIns(3,4,5)P3 signaling in neutrophils.EMBO reports · 2015Review
- Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes.Cellular and molecular life sciences : CMLS · 2014Review
- PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Loss of PTEN permits CXCR4-mediated tumorigenesis through ERK1/2 in prostate cancer cells.Molecular cancer research : MCR · 2011Article
- A beta version of life: p110β takes center stage.Oncotarget · 2010Review
- Immunological considerations of modern animal models of malignant primary brain tumors.Journal of translational medicine · 2009Review
- Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications.Molecular biology of the cell · 2009Article
- Assessment of PTEN tumor suppressor activity in nonmammalian models: the year of the yeast.Oncogene · 2008Review
- Video-rate two-photon imaging of mouse footpad - a promising model for studying leukocyte recruitment dynamics during inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2008Article
- Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions.Blood · 2007Article
- PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration.Current biology : CB · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a multifunctional tumor suppressor, has been shown to play a regulatory role in cell migration. Dictyostelium discoideum cells lacking PTEN exhibited impaired migration toward chemoattractant gradients. In the present study, we investigated the involvement of PTEN in chemotaxis of mammalian cells by examining PTEN-null Jurkat T cells. We observed that, in contrast to observations made in D discoideum, PTEN-null Jurkat T cells exhibited potent chemotactic responses to the chemokine stromal cell-derived factor 1alpha (SDF-1alpha), indicating that PTEN was not requisite for CXC chemokine receptor 4 (CXCR4)-mediated chemotaxis of Jurkat cells. Conversely, reconstitution of PTEN in Jurkat cells by using a tetracycline (Tet-on)-inducible expression system down-regulated CXCR4-mediated chemotaxis. Furthermore, we established the lipid phosphatase activity of PTEN as essential for its inhibitory effect on chemotaxis. In addition, using PTEN-expressing T-cell lines and primary T cells, we demonstrated that down-regulation of PTEN expression with vector-based small interfering RNAs (siRNAs) enhanced CXCR4-mediated chemotaxis. Based on these results, we conclude that PTEN expression negatively regulates chemotaxis of lymphoid mammalian cells via its lipid phosphatase activity. Our findings may account for the reported increase in metastatic activity of PTEN-null tumor cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.