ArticleProceedings of the National Academy of Sciences of the United States of America2005
Telomerase can act as a template- and RNA-independent terminal transferase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- CDK1 dependent phosphorylation of hTERT contributes to cancer progression.Nature communications · 2020Article
- Effect of therapies-mediated modulation of telomere and/or telomerase on cancer cells radiosensitivity.Oncotarget · 2018Review
- New prospects for targeting telomerase beyond the telomere.Nature reviews. Cancer · 2016Review
- De Novo RNA Synthesis by RNA-Dependent RNA Polymerase Activity of Telomerase Reverse Transcriptase.Molecular and cellular biology · 2016Article
- Manganese redistribution by calcium-stimulated vesicle trafficking bypasses the need for P-type ATPase function.The Journal of biological chemistry · 2015Article
- Involvement of telomerase reverse transcriptase in heterochromatin maintenance.Molecular and cellular biology · 2014Article
- Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes.Nucleic acids research · 2014Article
- Protein-primed terminal transferase activity of hepatitis B virus polymerase.Journal of virology · 2013Article
- Impaired manganese metabolism causes mitotic misregulation.The Journal of biological chemistry · 2012Article
- Telomere lengthening and other functions of telomerase.Acta naturae · 2012Article
- RNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency.The EMBO journal · 2012Article
- Article
- Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria.Nucleic acids research · 2012Article
- Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria.Frontiers in oncology · 2012Article
- A widespread class of reverse transcriptase-related cellular genes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Separation of telomerase functions by reverse genetics.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Single-stranded DNA repeat synthesis by telomerase.Current opinion in chemical biology · 2011Review
- A reverse transcriptase-related protein mediates phage resistance and polymerizes untemplated DNA in vitro.Nucleic acids research · 2011Article
- Ribonucleoprotein multimers and their functions.Critical reviews in biochemistry and molecular biology · 2010Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Telomerase is a special reverse transcriptase that extends one strand of the telomere repeat by using a template embedded in an RNA subunit. Like other polymerases, telomerase is believed to use a pair of divalent metal ions (coordinated by a triad of aspartic acid residues) for catalyzing nucleotide addition. Here we show that, in the presence of manganese, both yeast and human telomerase can switch to a template- and RNA-independent mode of DNA synthesis, acting in effect as a terminal transferase. Even as a terminal transferase, yeast telomerase retains a species-dependent preference for GT-rich, telomere-like DNA on the 5' end of the substrate. The terminal transferase activity of telomerase may account for some of the hitherto unexplained effects of telomerase overexpression on cell physiology.
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