ArticleWorld journal of gastroenterology2005
Expression and significance of tumor-related genes in HCC.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Glypican-3 Expression in Patients with Oral Squamous Cell Carcinoma.Journal of dentistry (Shiraz, Iran) · 2020Article
- A Phase I Study of Ribociclib Plus Everolimus in Patients with Metastatic Pancreatic Adenocarcinoma Refractory to Chemotherapy.Journal of pancreatic cancer · 2020Article
- Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction.Toxicology research · 2019Article
- Expression of Markers of Hepatocellular Differentiation in Pancreatic Acinar Cell Neoplasms: A Potential Diagnostic Pitfall.American journal of clinical pathology · 2016Article
- Critical role of DEK and its regulation in tumorigenesis and metastasis of hepatocellular carcinoma.Oncotarget · 2016Article
- The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1α-dependent and -independent manners.Oncotarget · 2016Article
- RB/PLK1-dependent induced pathway by SLAMF3 expression inhibits mitosis and control hepatocarcinoma cell proliferation.Oncotarget · 2016Article
- Article
- Evaluation of circulating Transforming growth factor-beta1, Glypican-3 and Golgi protein-73 mRNAs expression as predictive markers for hepatocellular carcinoma in Egyptian patients.Molecular biology reports · 2013Article
- High SKIP expression is correlated with poor prognosis and cell proliferation of hepatocellular carcinoma.Medical oncology (Northwood, London, England) · 2013Article
- Article
- The application of a three-step serum proteome analysis for the discovery and identification of novel biomarkers of hepatocellular carcinoma.International journal of proteomics · 2012Article
- The human DEK oncogene stimulates β-catenin signaling, invasion and mammosphere formation in breast cancer.Oncogene · 2011Article
- Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma.World journal of hepatology · 2010Article
- DEK proto-oncogene expression interferes with the normal epithelial differentiation program.The American journal of pathology · 2009Article
- Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma.World journal of gastroenterology · 2008Article
- Serum tumor markers for detection of hepatocellular carcinoma.World journal of gastroenterology · 2006Review
- MicroRNA-499 Suppresses the Growth of Hepatocellular Carcinoma by Downregulating Astrocyte Elevated Gene-1.Technology in cancer research & treatmentArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the expression and clinical significance of DEK, cyclin D1, insulin-like growth factor II (IGF-II), glypican 3 (GPC3), ribosomal phosphoprotein 0 (rpP0) mRNA in hepatocellular carcinoma (HCC) and its paraneoplastic tissues.
methodsThe expression of mRNAs of DEK, cyclin D1, IGF-II, GPC3 and rpP0 mRNA was detected in HCC and its paraneoplastic tissues by multiplex RT-PCR.
resultsBy the simplex RT-PCR, the overexpression of mRNAs of DEK, cyclin D1, IGF-II, GPC3, rpP0 mRNA in HCC and its paraneoplastic tissues was 78.1%, 87.5%, 87.5%, 75.0%, 81.3% and 15.6%, 40.6%, 37.5%, 21.9%, 31.3% respectively (P<0.05). By the multiplex RT-PCR, at least one of the mRNAs was detected in all HCC samples and in 75.0% of paraneoplastic samples (P>0.05). However, all these five mRNAs were found in 68.8% of HCC samples, but only in 9.4% of paraneoplastic tissues (P<0.05). The positive expression of mRNAs of DEK, cyclin D1, IGF-II, GPC3, rpP0 in well- and poorly-differentiated HCC was 89.0%, 66.7%, 66.7%, 66.7%, 77.8% and 73.9%, 95.7%, 95.7%, 95.7%, 82.6%, respectively (P>0.05). The expression of these genes in HCCs with alpha-feto protein (AFP) negative and positive was 90.0%, 80.0%, 90.0%, 90.0%, 90.0% and 72.7%, 86.3%, 77.3%, 90.9%, 68.2% respectively (P>0.05).
conclusionThe expression of DEK, cyclin D1, IGF-II, GPC3, rpP0 mRNA in HCC is much higher in HCC than in its paraneoplastic tissues. Multiplex RT-PCR assay is an effective, sensitive, accurate, and cost-effective diagnostic method of HCC.
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