Trial reportExperimental brain research2005
Modification of motor cortical excitability by an acetylcholinesterase inhibitor.
Trial report in Experimental brain research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Cortical excitability in smoking and not smoking individuals with and without nicotine.Psychopharmacology · 2013Trial
- Nicotinergic impact on focal and non-focal neuroplasticity induced by non-invasive brain stimulation in non-smoking humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Trial
- Gating of Neuroplasticity: Effects and Mechanisms of Acute Aerobic Exercise as a Brain Stimulation for the Sensorimotor Cortex.Advances in neurobiology · 2025Review
- Effect of high-frequency (5Hz) rTMS stimulating left DLPFC combined with galantamine on cognitive impairment after ischemic stroke and serum homocysteine and neuron-specific enolase.Frontiers in neurology · 2024Article
- Modulating Neural Circuits with Transcranial Magnetic Stimulation: Implications for Addiction Treatment Development.Pharmacological reviews · 2018Review
- Corticospinal excitability is associated with hypocapnia but not changes in cerebral blood flow.The Journal of physiology · 2016Article
- A comprehensive study of sensorimotor cortex excitability in chronic cocaine users: Integrating TMS and functional MRI data.Drug and alcohol dependence · 2015Article
- Modulation of the cortical silent period elicited by single- and paired-pulse transcranial magnetic stimulation.BMC neuroscience · 2013Article
- Differential pharmacological effects on brain reactivity and plasticity in Alzheimer's disease.Frontiers in psychiatry · 2013Article
- Intra- and inter-cortical motor excitability in Alzheimer's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2012Article
- Combining transcranial magnetic stimulation and electroencephalography may contribute to assess the severity of Alzheimer's disease.International journal of Alzheimer's disease · 2011Article
- Transcranial magnetic stimulation, synaptic plasticity and network oscillations.Journal of neuroengineering and rehabilitation · 2009Review
- L-dopa modulates motor cortex excitability in Alzheimer's disease patients.Journal of neural transmission (Vienna, Austria : 1996) · 2008Article
- A neural network model of attention-modulated neurodynamics.Cognitive neurodynamics · 2007Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetylcholine powerfully modulates the excitability of neocortical neurones and networks. This study applied focal transcranial magnetic stimulation (TMS) to eight healthy subjects to test the effects of a single oral dose of 40 mg tacrine, an acetylcholinesterase inhibitor, on motor cortical excitability. It was found that tacrine decreased short-interval intracortical inhibition, and increased intracortical facilitation and short-interval intracortical facilitation. Motor thresholds, motor evoked potential amplitude, cortical silent period (CSP) duration, and measures of spinal and neuromuscular excitability remained unchanged. The effects peaked at 2-6 h and fully reversed after 24 h. All effects can be explained by a reduction of motor cortical GABAergic inhibitory neurotransmission via activation of presynaptic muscarinic M2 receptors, but other more complex mechanisms may also have contributed and are discussed. The findings predict that acetylcholine has the potential to promote plasticity and learning in human motor cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.