ArticleThe EMBO journal2005
Homolog of BRCA2-interacting Dss1p and Uap56p link Mlo3p and Rae1p for mRNA export in fission yeast.
Article in The EMBO journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 47 citations in OpenAlex.
- piRNA- and siRNA-mediated transcriptional repression in Drosophila, mice, and yeast: new insights and biodiversity.EMBO reports · 2021Review
- Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription.Communications biology · 2019Article
- Article
- A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control.PLoS genetics · 2017Article
- Functional and regulatory profiling of energy metabolism in fission yeast.Genome biology · 2016Article
- RNA Export through the NPC in Eukaryotes.Genes · 2015Review
- Enriching the pore: splendid complexity from humble origins.Traffic (Copenhagen, Denmark) · 2014Review
- DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.Protein & cell · 2014Article
- DSSylation, a novel guide for protein degradation?Protein & cell · 2014Article
- RNAi function, diversity, and loss in the fungal kingdom.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.Nucleic acids research · 2013Article
- Article
- Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.BMC genomics · 2012Article
- Isolation of a novel rmn1 gene genetically linked to spnab2 with respect to mRNA export in fission yeast.Molecules and cells · 2012Article
- Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin.Nature structural & molecular biology · 2011Article
- Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.Science (New York, N.Y.) · 2011Article
- The cellular DExD/H-box RNA-helicases UAP56 and URH49 exhibit a CRM1-independent nucleocytoplasmic shuttling activity.PloS one · 2011Article
- Isolation of synthetic lethal mutations in the rsm1-null mutant of fission yeast.Journal of microbiology (Seoul, Korea) · 2010Article
- Designed proteins to modulate cellular networks.ACS chemical biology · 2010Article
- Schizosaccharomyces pombe Dss1p is a DNA damage checkpoint protein that recruits Rad24p, Cdc25p, and Rae1p to DNA double-strand breaks.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The breast cancer tumor suppressor BRCA2-interacting protein, DSS1, and its homologs are critical for DNA recombination in eukaryotic cells. We found that Dss1p, along with Mlo3p and Uap56p, Schizosaccharomyces pombe homologs of two messenger RNA (mRNA) export factors of the NXF-NXT pathway, is required for mRNA export in S. pombe. Previously, we showed that the nuclear pore-associated Rae1p is an essential mRNA export factor in S. pombe. Here, we show that Dss1p and Uap56p function by linking mRNA adapter Mlo3p to Rae1p for targeting mRNA-protein complex (mRNP) to the proteins of the nuclear pore complex (NPC). Dss1p preferentially recruits to genes in vivo and interacts with -FG (phenylalanine glycine) nucleoporins in vivo and in vitro. Thus, Dss1p may function at multiple steps of mRNA export, from mRNP biogenesis to their targeting and translocation through the NPC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.