Trial reportMetabolism: clinical and experimental2005
Modest weight loss improves insulin action in obese African Americans.
Trial report in Metabolism: clinical and experimental, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents.Obesity (Silver Spring, Md.) · 2009Trial
- Continuous Exposure of Nonobese Adult Male Rats to a Soft-Textured, Readily Absorbable Diet Induces Insulin Resistance and Derangements in Hepatic Glucose and Lipid Metabolism.The Journal of nutrition · 2025Article
- CT Quantitation and Prediction of the Risk of Type 2 Diabetes Mellitus in Non-Obese Patients with Pancreatic Fatty Infiltration.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Derivation and Validation of a Prediction Model for Predicting the 5-Year Incidence of Type 2 Diabetes in Non-Obese Adults: A Population-Based Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- The effect of health shocks on smoking and obesity.The European journal of health economics : HEPAC : health economics in prevention and care · 2012Article
- Bayesian functional integral method for inferring continuous data from discrete measurements.Biophysical journal · 2012Article
- High blood pressure and obesity increase the risk of abnormal glucose tolerance in young adult african americans.Journal of clinical hypertension (Greenwich, Conn.) · 2011Article
- HCV synergizes with body weight in the promotion of insulin resistance.Journal of viral hepatitis · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe have previously shown that short-term energy restriction followed by modest lifestyle changes improves glucose tolerance for up to 1 year in obese individuals. The purpose of the present study was to determine the mechanism by which improvements in glucose tolerance occur in obese African Americans with insulin resistance and abnormal glucose tolerance. RESEARCH DESIGN AND
methodsNine subjects (53 +/- 2 years; body mass index, 37 +/- 3 kg/m 2 [mean +/- SEM]) received a low-energy diet (3883 +/- 222 kJ/d) for 1 week, and then followed a modest lifestyle intervention program for up to 1 year. Body composition was estimated by hydrostatic weighing, and insulin secretion and action were assessed during a hyperglycemic clamp with superimposed arginine infusion and fat meal. Baseline and final tests were performed during weight stability.
resultsSignificant improvements ( P < .05) were observed for body weight (-6.1 +/- 1.1 kg), body composition (-5.5 +/- 1.3 kg fat mass), fasting plasma glucose (-1.1 +/- 0.3 mmol/L), fasting insulin (-52 +/- 21 pmol/L), oral glucose tolerance, and insulin action (+24%), defined as an increase in glucose disposal rate relative to plasma insulin concentration during the hyperglycemic clamp. These improvements were independent of an acute effect of energy restriction or weight loss, because body weight was stable.
conclusionsThese results suggest that the improvements in glucose tolerance with a modest lifestyle intervention were attributable to an improvement in insulin action, and provide evidence that despite persistent obesity (body mass index, 34.7 +/- 2.4 kg/m 2 ), long-term benefits can be achieved with relatively small weight loss in obese African Americans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.