ArticleAmerican journal of human genetics2005
A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics.
Article in American journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.
- Association of 17q24 rs1859962 gene polymorphism with prostate cancer risk: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Coregulators determine androgen receptor activity in prostate cancer.Bioscience reports · 2025Review
- Two-stage Study of Familial Prostate Cancer by Whole-exome Sequencing and Custom Capture Identifies 10 Novel Genes Associated with the Risk of Prostate Cancer.European urology · 2021Article
- Review
- 8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer.Nature communications · 2020Article
- Prostate Cancer Germline Variations and Implications for Screening and Treatment.Cold Spring Harbor perspectives in medicine · 2018Review
- Article
- Germline genetic profiling in prostate cancer: latest developments and potential clinical applications.Future science OA · 2016Review
- Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Article
- Fine-mapping the 2q37 and 17q11.2-q22 loci for novel genes and sequence variants associated with a genetic predisposition to prostate cancer.International journal of cancer · 2015Article
- Mutational landscape of candidate genes in familial prostate cancer.The Prostate · 2014Article
- Fine-mapping the HOXB region detects common variants tagging a rare coding allele: evidence for synthetic association in prostate cancer.PLoS genetics · 2014Article
- Dysregulation of the homeobox transcription factor gene HOXB13: role in prostate cancer.Pharmacogenomics and personalized medicine · 2014Review
- The genetic epidemiology of prostate cancer and its clinical implications.Nature reviews. Urology · 2014Review
- Article
- Prostate cancer risk-associated genetic markers and their potential clinical utility.Asian journal of andrology · 2013Article
- HOXB13 mutation and prostate cancer: studies of siblings and aggressive disease.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis.BMC cancer · 2013Article
- Familial prostate cancer: the damage done and lessons learnt.Nature reviews. Urology · 2013Article
- Article
Corrections and comments
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Authors and funding
72 authors at 8 institutions in 4 countries.
Funding
Abstract
Evidence of the existence of major prostate cancer (PC)-susceptibility genes has been provided by multiple segregation analyses. Although genomewide screens have been performed in over a dozen independent studies, few chromosomal regions have been consistently identified as regions of interest. One of the major difficulties is genetic heterogeneity, possibly due to multiple, incompletely penetrant PC-susceptibility genes. In this study, we explored two approaches to overcome this difficulty, in an analysis of a large number of families with PC in the International Consortium for Prostate Cancer Genetics (ICPCG). One approach was to combine linkage data from a total of 1,233 families to increase the statistical power for detecting linkage. Using parametric (dominant and recessive) and nonparametric analyses, we identified five regions with "suggestive" linkage (LOD score >1.86): 5q12, 8p21, 15q11, 17q21, and 22q12. The second approach was to focus on subsets of families that are more likely to segregate highly penetrant mutations, including families with large numbers of affected individuals or early age at diagnosis. Stronger evidence of linkage in several regions was identified, including a "significant" linkage at 22q12, with a LOD score of 3.57, and five suggestive linkages (1q25, 8q13, 13q14, 16p13, and 17q21) in 269 families with at least five affected members. In addition, four additional suggestive linkages (3p24, 5q35, 11q22, and Xq12) were found in 606 families with mean age at diagnosis of < or = 65 years. Although it is difficult to determine the true statistical significance of these findings, a conservative interpretation of these results would be that if major PC-susceptibility genes do exist, they are most likely located in the regions generating suggestive or significant linkage signals in this large study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.