ArticleNeuroinformatics2005
Development of a model for microphysiological simulations: small nodes of ranvier from peripheral nerves of mice reconstructed by electron tomography.
Article in Neuroinformatics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Handling Difficult Cryo-ET Samples: A Study with Primary Neurons from Drosophila melanogaster.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2023Article
- An intelligent workflow for sub-nanoscale 3D reconstruction of intact synapses from serial section electron tomography.BMC biology · 2023Article
- Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain.Developmental cell · 2021Article
- Age Mosaicism across Multiple Scales in Adult Tissues.Cell metabolism · 2019Article
- Location Specificity of Transcranial Electrical Stimulation on Neuronal Electrodynamics: A Mathematical Model of Ion Channel Gating Dynamics and Ionic Flux Due to Neurostimulation.Frontiers in computational neuroscience · 2019Article
- Article
- Minimizing the caliber of myelinated axons by means of nodal constrictions.Journal of neurophysiology · 2015Article
- Inner ear tissue preservation by rapid freezing: improving fixation by high-pressure freezing and hybrid methods.Hearing research · 2014Article
- Cardiac myocytes and local signaling in nano-domains.Progress in biophysics and molecular biology · 2011Review
- Systems biology in immunology: a computational modeling perspective.Annual review of immunology · 2011Review
- Mitochondrial configurations in peripheral nerve suggest differential ATP production.Journal of structural biology · 2011Article
- Imbalance of ionic conductances contributes to diverse symptoms of demyelination.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The structural dynamics of macromolecular processes.Current opinion in cell biology · 2009Review
- Computational modeling of three-dimensional electrodiffusion in biological systems: application to the node of Ranvier.Biophysical journal · 2008Article
- The combination of chemical fixation procedures with high pressure freezing and freeze substitution preserves highly labile tissue ultrastructure for electron tomography applications.Journal of structural biology · 2008Article
- Expedited approaches to whole cell electron tomography and organelle mark-up in situ in high-pressure frozen pancreatic islets.Journal of structural biology · 2008Article
- The cell centered database project: an update on building community resources for managing and sharing 3D imaging data.Journal of structural biology · 2008Article
- Electron tomographic analysis of cytoskeletal cross-bridges in the paranodal region of the node of Ranvier in peripheral nerves.Journal of structural biology · 2008Article
- A formal ontology of subcellular neuroanatomy.Frontiers in neuroinformatics · 2007Article
- Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method.PLoS computational biology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The node of Ranvier is a complex structure found along myelinated nerves of vertebrate animals. Specific membrane, cytoskeletal, junctional, extracellular matrix proteins and organelles interact to maintain and regulate associated ion movements between spaces in the nodal complex, potentially influencing response variation during repetitive activations or metabolic stress. Understanding and building high resolution three dimensional (3D) structures of the node of Ranvier, including localization of specific macromolecules, is crucial to a better understanding of the relationship between its structure and function and the macromolecular basis for impaired conduction in disease. Using serial section electron tomographic methods, we have constructed accurate 3D models of the nodal complex from mouse spinal roots with resolution better than 7.5 nm. These reconstructed volumes contain 75-80% of the thickness of the nodal region. We also directly imaged the glial axonal junctions that serve to anchor the terminal loops of the myelin lamellae to the axolemma. We created a model of an intact node of Ranvier by truncating the volume at its midpoint in Z, duplicating the remaining volume and then merging the new half volume with mirror symmetry about the Z-axis. We added to this model the distribution and number of Na+ channels on this reconstruction using tools associated with the MCell simulation program environment. The model created provides accurate structural descriptions of the membrane compartments, external spaces, and formed structures enabling more realistic simulations of the role of the node in modulation of impulse propagation than have been conducted on myelinated nerve previously.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.