ArticleMolecular and cellular biology2005
Sum1p, the origin recognition complex, and the spreading of a promoter-specific repressor in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae.Genetics · 2016Review
- Determinants of Sir2-Mediated, Silent Chromatin Cohesion.Molecular and cellular biology · 2016Article
- The transcriptional repressor Sum1p counteracts Sir2p in regulation of the actin cytoskeleton, mitochondrial quality control and replicative lifespan inMicrobial cell (Graz, Austria) · 2016Article
- Genome-wide analysis of functional sirtuin chromatin targets in yeast.Genome biology · 2013Article
- A Link between ORC-origin binding mechanisms and origin activation time revealed in budding yeast.PLoS genetics · 2013Article
- The Sum1/Ndt80 transcriptional switch and commitment to meiosis in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2012Review
- A region of the nucleosome required for multiple types of transcriptional silencing in Saccharomyces cerevisiae.Genetics · 2011Article
- Modeling of chromosomal epigenetic silencing processes.Transcription · 2011Article
- The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin.Genes & development · 2010Article
- An auxiliary silencer and a boundary element maintain high levels of silencing proteins at HMR in Saccharomyces cerevisiae.Genetics · 2010Article
- The Sir2-Sum1 complex represses transcription using both promoter-specific and long-range mechanisms to regulate cell identity and sexual cycle in the yeast Kluyveromyces lactis.PLoS genetics · 2009Article
- A silencer promotes the assembly of silenced chromatin independently of recruitment.Molecular and cellular biology · 2009Article
- Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase.BMC molecular biology · 2008Article
- Evolution of new function through a single amino acid change in the yeast repressor Sum1p.Molecular and cellular biology · 2008Article
- Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2.Molecular and cellular biology · 2008Article
- Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p.BMC biology · 2007Article
- Substitution as a mechanism for genetic robustness: the duplicated deacetylases Hst1p and Sir2p in Saccharomyces cerevisiae.PLoS genetics · 2007Article
- Swapping the gene-specific and regional silencing specificities of the Hst1 and Sir2 histone deacetylases.Molecular and cellular biology · 2007Article
- Analyses of SUM1-1-mediated long-range repression.Genetics · 2006Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In Saccharomyces cerevisiae, Sum1p is a promoter-specific repressor. A single amino acid change generates the mutant Sum1-1p, which causes regional silencing at new loci where wild-type Sum1p does not act. Thus, Sum1-1p is a model for understanding how the spreading of repressive chromatin is regulated. When wild-type Sum1p was targeted to a locus where mutant Sum1-1p spreads, wild-type Sum1p did not spread as efficiently as mutant Sum1-1p did, despite being in the same genomic context. Thus, the SUM1-1 mutation altered the ability of the protein to spread. The spreading of Sum1-1p required both an enzymatically active deacetylase, Hst1p, and the N-terminal tail of histone H4, consistent with the spreading of Sum1-1p involving sequential modification of and binding to histone tails, as observed for other silencing proteins. Furthermore, deletion of the N-terminal tail of H4 caused Sum1-1p to return to loci where wild-type Sum1p acts, consistent with the SUM1-1 mutation increasing the affinity of the protein for H4 tails. These results imply that the spreading of repressive chromatin proteins is regulated by their affinities for histone tails. Finally, this study uncovered a functional connection between wild-type Sum1p and the origin recognition complex, and this relationship also contributes to mutant Sum1-1p localization.
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