ArticleRNA (New York, N.Y.)2005
A surprisingly large RNase P RNA in Candida glabrata.
Article in RNA (New York, N.Y.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Interaction Networks of Ribosomal Expansion Segments in Kinetoplastids.Sub-cellular biochemistry · 2021Review
- Piece by piece: Building a ribozyme.The Journal of biological chemistry · 2020Review
- Revisiting the Closed-Loop Model and the Nature of mRNA 5'-3' Communication.Molecular cell · 2018Review
- Review
- Structural Roles of Noncoding RNAs in the Heart of Enzymatic Complexes.Biochemistry · 2017Article
- Defining the transcriptomic landscape of Candida glabrata by RNA-Seq.Nucleic acids research · 2015Article
- Gene expansion shapes genome architecture in the human pathogen Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient terrestrial mucorales (Mucoromycotina).PLoS genetics · 2014Article
- Genome structure and dynamics of the yeast pathogen Candida glabrata.FEMS yeast research · 2014Review
- Comparative genomics of emerging pathogens in the Candida glabrata clade.BMC genomics · 2013Article
- Archaeal/eukaryal RNase P: subunits, functions and RNA diversification.Nucleic acids research · 2010Review
- Lipoic acid metabolism in microbial pathogens.Microbiology and molecular biology reviews : MMBR · 2010Review
- Experimental annotation of the human pathogen Candida albicans coding and noncoding transcribed regions using high-resolution tiling arrays.Genome biology · 2010Article
- The tedious task of finding homologous noncoding RNA genes.RNA (New York, N.Y.) · 2009Article
- Multiplex real-time PCR targeting the RNase P RNA gene for detection and identification of Candida species in blood.Journal of clinical microbiology · 2007Article
- Sequence analysis of RNase MRP RNA reveals its origination from eukaryotic RNase P RNA.RNA (New York, N.Y.) · 2006Article
- The RNA polymerase III-dependent family of genes in hemiascomycetes: comparative RNomics, decoding strategies, transcription and evolutionary implications.Nucleic acids research · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have found an extremely large ribonuclease P (RNase P) RNA (RPR1) in the human pathogen Candida glabrata and verified that this molecule is expressed and present in the active enzyme complex of this hemiascomycete yeast. A structural alignment of the C. glabrata sequence with 36 other hemiascomycete RNase P RNAs (abbreviated as P RNAs) allows us to characterize the types of insertions. In addition, 15 P RNA sequences were newly characterized by searching in the recently sequenced genomes Candida albicans, C. glabrata, Debaryomyces hansenii, Eremothecium gossypii, Kluyveromyces lactis, Kluyveromyces waltii, Naumovia castellii, Saccharomyces kudriavzevii, Saccharomyces mikatae, and Yarrowia lipolytica; and by PCR amplification for other Candida species (Candida guilliermondii, Candida krusei, Candida parapsilosis, Candida stellatoidea, and Candida tropicalis). The phylogenetic comparative analysis identifies a hemiascomycete secondary structure consensus that presents a conserved core in all species with variable insertions or deletions. The most significant variability is found in C. glabrata P RNA in which three insertions exceeding in total 700 nt are present in the Specificity domain. This P RNA is more than twice the length of any other homologous P RNAs known in the three domains of life and is eight times the size of the smallest. RNase P RNA, therefore, represents one of the most diversified noncoding RNAs in terms of size variation and structural diversity.
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