ArticleRNA (New York, N.Y.)2005
Genome-wide analyses of two families of snoRNA genes from Drosophila melanogaster, demonstrating the extensive utilization of introns for coding of snoRNAs.
Article in RNA (New York, N.Y.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 75 citations in OpenAlex.
- SnoRNA Expression and RNA 2'-O-Methylation inbioRxiv : the preprint server for biology · 2026Article
- A U3 snoRNA is required for the regulation of chromatin dynamics and antiviral response in Drosophila melanogaster.Nucleic acids research · 2025Article
- SnoBIRD: a tool to identify C/D box snoRNAs and refine their annotation across all eukaryotes.Nucleic acids research · 2025Article
- Transcriptome-wide analysis of pseudouridylation in Drosophila melanogaster.G3 (Bethesda, Md.) · 2023Article
- Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution.Nucleic acids research · 2022Article
- Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila.Nature communications · 2020Article
- tRNA Fragments Populations Analysis in Mutants Affecting tRNAs Processing and tRNA Methylation.Frontiers in genetics · 2020Article
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- Transcriptional regulation of snRNAs and its significance for plant development.Journal of plant research · 2017Review
- SnoReport 2.0: new features and a refined Support Vector Machine to improve snoRNA identification.BMC bioinformatics · 2016Article
- TissueMiner: A multiscale analysis toolkit to quantify how cellular processes create tissue dynamics.eLife · 2016Article
- Unusual Novel SnoRNA-Like RNAs in Drosophila melanogaster.Non-coding RNA · 2015Article
- Deletion of Drosophila Nopp140 induces subcellular ribosomopathies.Chromosoma · 2015Article
- snoRNAs are a novel class of biologically relevant Myc targets.BMC biology · 2015Article
- Sex-specific trans-regulatory variation on the Drosophila melanogaster X chromosome.PLoS genetics · 2015Article
- Genome-wide analysis of small nucleolar RNAs of Leishmania major reveals a rich repertoire of RNAs involved in modification and processing of rRNA.RNA biology · 2015Article
- Identification of discrete classes of small nucleolar RNA featuring different ends and RNA binding protein dependency.Nucleic acids research · 2014Article
- Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila.Nucleic acids research · 2013Article
- Deep sequencing the circadian and diurnal transcriptome of Drosophila brain.Genome research · 2012Article
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small nucleolar RNAs (snoRNAs) are an abundant group of noncoding RNAs mainly involved in the post-transcriptional modifications of rRNAs in eukaryotes. In this study, a large-scale genome-wide analysis of the two major families of snoRNA genes in the fruit fly Drosophila melanogaster has been performed using experimental and computational RNomics methods. Two hundred and twelve gene variants, encoding 56 box H/ACA and 63 box C/D snoRNAs, were identified, of which 57 novel snoRNAs have been reported for the first time. These snoRNAs were predicted to guide a total of 147 methylations and pseudouridylations on rRNAs and snRNAs, showing a more comprehensive pattern of rRNA modification in the fruit fly. With the exception of nine, all the snoRNAs identified to date in D. melanogaster are intron encoded. Remarkably, the genomic organization of the snoRNAs is characteristic of 8 dUhg genes and 17 intronic gene clusters, demonstrating that distinct organizations dominate the expression of the two families of snoRNAs in the fruit fly. Of the 267 introns in the host genes, more than half have been identified as host introns for coding of snoRNAs. In contrast to mammals, the variation in size of the host introns is mainly due to differences in the number of snoRNAs they contain. These results demonstrate the extensive utilization of introns for coding of snoRNAs in the host genes and shed light on further research of other noncoding RNA genes in the large introns of the Drosophila genome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.