ArticleBreast cancer research : BCR2005
Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study.
Article in Breast cancer research : BCR, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 4 of them syntheses that pooled it.
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Who cites it
84 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Advances in the Prevention and Treatment of Obesity-Driven Effects in Breast Cancers.Frontiers in oncology · 2022Pooled it
- Adolescent and Childhood Obesity and Excess Morbidity and Mortality in Young Adulthood-a Systematic Review.Current obesity reports · 2021Pooled it
- Association of the Age at Menarche with Site-Specific Cancer Risks in Pooled Data from Nine Cohorts.Cancer research · 2021Pooled it
- Adiposity and cancer at major anatomical sites: umbrella review of the literature.BMJ (Clinical research ed.) · 2017Pooled it
- Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Trial
- Evaluating the consequences of childhood adiposity on the human plasma proteome at four timepoints across the lifecourse.Nature communications · 2026Article
- Nutrition Across the Life Course and Risk of Young-Onset Breast Cancer: Mechanisms, Evidence, and Prevention Opportunities.Nutrients · 2026Review
- PCOS and breast cancer risk: hormonal modulation and epidemiological trends.Reproductive health · 2026Review
- Investigating the causal effects of childhood and adulthood adiposity on later life mental health outcome: a Mendelian randomization study.BMC medicine · 2025Article
- Implications of obesity and insulin resistance for the treatment of oestrogen receptor-positive breast cancer.British journal of cancer · 2024Review
- Genetic associations of birthweight, childhood, and adult BMI with metabolic dysfunction-associated steatotic liver disease: a Mendelian randomization.BMC gastroenterology · 2024Article
- Association of early menarche with breast tumor molecular features and recurrence.Breast cancer research : BCR · 2024Article
- Early puberty: a review on its role as a risk factor for metabolic and mental disorders.Frontiers in pediatrics · 2024Review
- Article
- Birthweight, childhood body size, and timing of puberty and risks of breast cancer by menopausal status and tumor receptor subtypes.Breast cancer research : BCR · 2022Article
- Obesity and Breast Cancer Risk: The Oncogenic Implications of Metabolic Dysregulation.The Journal of clinical endocrinology and metabolism · 2022Article
- Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization.PLoS genetics · 2022Article
- Sugar-sweetened beverage consumption and breast composition in a longitudinal study of Chilean girls.Breast cancer research : BCR · 2022Article
- Body Fat Distribution and Risk of Breast, Endometrial, and Ovarian Cancer: A Two-Sample Mendelian Randomization Study.Cancers · 2021Article
- Separating the genetics of childhood and adult obesity: a validation study of genetic scores for body mass index in adolescence and adulthood in the HUNT Study.Human molecular genetics · 2021Article
24 more citing papers are in PubMed but not listed here.
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Funding
Abstract
introductionBody mass index (BMI) during adulthood is inversely related to the incidence of premenopausal breast cancer, but the role of body fatness earlier in life is less clear. We examined prospectively the relation between body fatness during childhood and adolescence and the incidence of breast cancer in premenopausal women.
methodsParticipants were 109,267 premenopausal women in the Nurses' Health Study II who recalled their body fatness at ages 5, 10 and 20 years using a validated 9-level figure drawing. Over 12 years of follow up, 1318 incident cases of breast cancer were identified. Cox proportional hazards regression was used to compute relative risks (RRs) and 95% confidence intervals (CIs) for body fatness at each age and for average childhood (ages 5-10 years) and adolescent (ages 10-20 years) fatness.
resultsBody fatness at each age was inversely associated with premenopausal breast cancer incidence; the multivariate RRs were 0.48 (95% CI 0.35-0.55) and 0.57 (95% CI 0.39-0.83) for the most overweight compared with the most lean in childhood and adolescence, respectively (P for trend < 0.0001). The association for childhood body fatness was only slightly attenuated after adjustment for later BMI, with a multivariate RR of 0.52 (95% CI 0.38-0.71) for the most overweight compared with the most lean (P for trend = 0.001). Adjustment for menstrual cycle characteristics had little impact on the association.
conclusionGreater body fatness during childhood and adolescence is associated with reduced incidence of premenopausal breast cancer, independent of adult BMI and menstrual cycle characteristics.
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