Trial reportCritical care (London, England)2005
Adhesion of the probiotic bacterium Lactobacillus plantarum 299v onto the gut mucosa in critically ill patients: a randomised open trial.
Trial report in Critical care (London, England), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Role of probiotic supplementation in preventing ventilator-associated pneumonia among critically ill patients-a critical umbrella review of meta-analyses of randomized controlled trials.Frontiers in nutrition · 2025Pooled it
- Synbiotic Therapy Prevents Nosocomial Infection in Critically Ill Adult Patients: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials Based on a Bayesian Framework.Frontiers in medicine · 2021Pooled it
- Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis.Critical care (London, England) · 2016Pooled it
- Use of probiotics to correct dysbiosis of normal microbiota following disease or disruptive events: a systematic review.BMJ open · 2014Pooled it
- Administration of probiotics to healthy volunteers: effects on reactivity of intestinal mucosa and systemic leukocytes.BMC gastroenterology · 2022Trial
- Can probiotics be an alternative to chlorhexidine for oral care in the mechanically ventilated patient? A multicentre, prospective, randomised controlled open trial.Critical care (London, England) · 2018Trial
- The safety and feasibility of probiotics in children and adolescents undergoing hematopoietic cell transplantation.Bone marrow transplantation · 2016Trial
- Synbiotic therapy reduces the pathological gram-negative rods caused by an increased acetic acid concentration in the gut.Digestive diseases and sciences · 2012Trial
- Use of the probiotic Lactobacillus plantarum 299 to reduce pathogenic bacteria in the oropharynx of intubated patients: a randomised controlled open pilot study.Critical care (London, England) · 2008Trial
- Isolation, Functional Screening, and Genomic Characterization of a Potential Probiotic Lactiplantibacillus Plantarum MP49 from Traditionally Fermented Bamboo Shoots of Tripura, India.Probiotics and antimicrobial proteins · 2026Article
- Probiotics and iron bioavailability: mechanisms, clinical evidence, and translational applications-a comprehensive review of the probiotic strainFrontiers in nutrition · 2026Review
- Wounds and the Microbiota: The Healing Interplay Between Host and Microbial Communities.International journal of molecular sciences · 2025Review
- Probiotic Potential and Enhanced Adhesion of Fermented Foods-Isolated Lactic Acid Bacteria to Intestinal Epithelial Caco-2 and HT-29 Cells.Microorganisms · 2024Article
- Article
- Probiotics in the Management of Mental and Gastrointestinal Post-COVID Symptomes.Journal of clinical medicine · 2022Review
- Efficacy of probiotics or synbiotics for critically ill adult patients: a systematic review and meta-analysis of randomized controlled trials.Burns & trauma · 2022Article
- Article
- Comparison of the effects ofMedical journal of the Islamic Republic of Iran · 2020Article
- Guidelines forPrzeglad gastroenterologiczny · 2020Article
- Effects of preoperative oral administration of glucose solution combined with postoperative probiotics on inflammation and intestinal barrier function in patients after colorectal cancer surgery.Oncology letters · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo achieve any possible positive effect on the intestinal mucosa cells it is important that probiotics adhere tightly onto the intestinal mucosa. It has been shown in healthy volunteers that Lactobacillus plantarum 299v (Lp 299v) (DSM 9843), a probiotic bacterium, given orally in a fermented oatmeal formula adheres onto the intestinal mucosa, but whether this also occurs in critically ill patients is unknown.
methodsAfter randomisation, nine enterally fed, critically ill patients treated with broad-spectrum antibiotics received an oatmeal formula fermented with Lp 299v throughout their stay in the intensive care unit; eight patients served as controls. Biopsies of the rectal mucosa were made at admission and then twice a week, and the biopsies were analysed blindly.
resultsFour patients in the control group were colonised with Lp 299v at admission but thereafter all their biopsies were negative (Lp 299v is an ingredient in a common functional food, ProViva, in Sweden). Of the treated patients none was colonised at admission but three patients had Lp 299v adhered on the mucosa from the second or third biopsy and in the following samples.
conclusionThis study shows that Lp 299v could survive the passage from the stomach to the rectum and was able adhere onto the rectal mucosa also in critically ill, antibiotic-treated patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.