ArticleParasite immunology2005
Schistosoma infection inhibits cellular immune responses to core HCV peptides.
Article in Parasite immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Association of the polymorphism of the Toll-like receptor (TLR)-3 and TLR-9 genes with hepatitis C virus-specific cell-mediated immunity outcomes among Egyptian health-care workers.Clinical and experimental immunology · 2021Trial
- From the discovery of helminths to the discovery of their carcinogenic potential.Parasitology research · 2023Review
- A cross sectional study of the risk factors of hepatitis C infection in North Egypt.Virusdisease · 2021Article
- Basic and associated causes of schistosomiasis-related mortality in Brazil: A population-based study and a 20-year time series of a disease still neglected.Journal of global health · 2021Article
- Effects of malaria/helminthic coinfections on cervical cancer progression among sub Saharan African women on highly active antiretroviral therapy: A scoping review.Gynecologic oncology reports · 2019Article
- Determining the HPV vaccine schedule for a HIV-infected population in sub Saharan Africa, a commentary.Virology journal · 2018Article
- Review
- Development of Complex Models to Study Co- and Polymicrobial Infections and Diseases.PLoS pathogens · 2016Article
- Interaction Between the Neglected Tropical Disease Human Schistosomiasis and HCV Infection in Egypt: a Puzzling Relationship.Journal of clinical and translational hepatology · 2014Review
- Schistosomiasis does not affect the outcome of HCV infection in genotype 4-infected patients.The American journal of tropical medicine and hygiene · 2014Article
- Cross reactive cellular immune response to HCV genotype 1 and 4 antigens among genotype 4 exposed subjects.PloS one · 2014Article
- Human schistosomiasis: clinical perspective: review.Journal of advanced research · 2013Review
- Hepatic and intestinal schistosomiasis: review.Journal of advanced research · 2013Review
- Chronic bystander infections and immunity to unrelated antigens.Cell host & microbe · 2012Review
- Hepatitis C virus-multispecific T-cell responses without viremia or seroconversion among Egyptian health care workers at high risk of infection.Clinical and vaccine immunology : CVI · 2012Article
- Schistosome: its benefit and harm in patients suffering from concomitant diseases.Journal of biomedicine & biotechnology · 2011Review
- Application of nanotechnologies for improved immune response against infectious diseases in the developing world.Advanced drug delivery reviews · 2010Review
- Diagnosing schistosomiasis by detection of cell-free parasite DNA in human plasma.PLoS neglected tropical diseases · 2009Article
- Seroprevalence and risk factors for human herpesvirus 8 infection, rural Egypt.Emerging infectious diseases · 2008Article
- Characterization of hepatitis E-specific cell-mediated immune response using IFN-gamma ELISPOT assay.Journal of immunological methods · 2007Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Patients coinfected with hepatitis C virus (HCV) and the trematode, Schistosoma mansoni, have an increased incidence of viral persistence and accelerated fibrosis. To investigate immunological mechanisms responsible for this more aggressive natural history of HCV, the core HCV-specific T-cell responses were analysed in 44 donated blood units rejected because they had antibodies to HCV (anti-HCV). Half also had anti-S. mansoni antibodies, evidence of past or active infection. HCV-specific ELISPOT responses were examined using pools of 180 overlapping 9-mer peptides with offsets of one covering the core of HCV genotype 4a. Comparison of T-cell responses in blood units positive for both anti-HCV and anti-Schistosoma antibodies with blood units positive only for anti-HCV antibodies showed a significant decrease in core-specific T-cell IFN-gamma (505+/- 46 vs. 803 +/- 66 ISC/10(6) cells, P < 0.001), IL-4 (2 +/- 108 vs. 641 +/- 131 ISC/10(6) cells, P < 0.001), and IL-10 (159 +/- 105 vs. 466 +/- 407 ISC/10(6) cells, P < 0.002) responses. In contrast, there was no significant difference in cell-mediated immune response (CMI) to PHA mitogen between these two groups. Therefore, we concluded T cells from persons with anti-Schistosoma have reduced IFN-gamma, IL-4, and IL-10 secreting HCV-specific T-cell responses. This may explain why Schistosoma coinfection increases persistence and severity of HCV infection.
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Registered trials
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