ArticleSynapse (New York, N.Y.)2005
Regional distribution and cellular localization of the ETS-domain transcription factor, FEV, mRNA in the human postmortem brain.
Article in Synapse (New York, N.Y.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Deconvolution-Based Transcriptomic Analysis in the Hippocampus Reveals Cell Type-Specific Risk Genes and Pathways Associated With Depression and Suicide.Biological psychiatry global open science · 2025Article
- Transcriptomic profiling across human serotonin neuron differentiation via the FEV reporter system.Stem cell research & therapy · 2024Article
- Embracing diversity in the 5-HT neuronal system.Nature reviews. Neuroscience · 2019Review
- Recessive gene disruptions in autism spectrum disorder.Nature genetics · 2019Article
- High fat diet decreases beneficial effects of estrogen on serotonin-related gene expression in marmosets.Progress in neuro-psychopharmacology & biological psychiatry · 2015Article
- GPR30 is necessary for estradiol-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the rat hypothalamus.Psychoneuroendocrinology · 2012Article
- Serotonergic transcriptional networks and potential importance to mental health.Nature neuroscience · 2012Review
- Molecular genetics of mouse serotonin neurons across the lifespan.Neuroscience · 2011Review
- Region-specific regulation of 5-HT1A receptor expression by Pet-1-dependent mechanisms in vivo.Journal of neurochemistry · 2011Article
- A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The expression of the transcription factor FEV in adult human brain and its association with affective disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2010Article
- Chronic social defeat downregulates the 5-HT1A receptor but not Freud-1 or NUDR in the rat prefrontal cortex.Neuroscience letters · 2010Article
- Medullary serotonin defects and respiratory dysfunction in sudden infant death syndrome.Respiratory physiology & neurobiology · 2009Review
- A passport to neurotransmitter identity.Genome biology · 2009Review
- Serotonergic transcription of human FEV reveals direct GATA factor interactions and fate of Pet-1-deficient serotonin neuron precursors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The ETS transcription factor Fifth Ewing Variant (FEV) mRNA, a homologue of the rodent Pet-1 gene that is exclusively expressed in serotonin-containing neurons and is a critical determinant of serotonin neuronal differentiation and development, was examined in human postmortem brain tissue using in situ hybridization histochemistry. Studies revealed that FEV mRNA is robustly and exclusively expressed in the major serotonin-containing cell groups of the dorsal and median raphe nuclei located in the midbrain and pons of the human brainstem. The localization of transcription factor, FEV, mRNA in serotonin-containing neurons of the human brain raises questions regarding the functional significance of this transcription factor in regulating serotonin-related genes and its potential role in psychiatric illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.