ArticlePsychopharmacology2005
Reinforcing effects of modafinil: influence of dose and behavioral demands following drug administration.
Article in Psychopharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 85 citations in OpenAlex.
- Modafinil and sleep architecture in an inpatient-outpatient treatment study of cocaine dependence.Drug and alcohol dependence · 2016Trial
- Trial
- Effects of modafinil on non-verbal cognition, task enjoyment and creative thinking in healthy volunteers.Neuropharmacology · 2013Trial
- Evaluation of modafinil effects on cardiovascular, subjective, and reinforcing effects of methamphetamine in methamphetamine-dependent volunteers.Drug and alcohol dependence · 2010Trial
- Acute physiological and behavioral effects of intranasal methamphetamine in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008Trial
- Amphetamine increases motivation of humans and mice as measured by breakpoint, but does not affect an Electroencephalographic biomarker.Cognitive, affective & behavioral neuroscience · 2024Article
- Modafinil, an atypical CNS stimulant?Advances in pharmacology (San Diego, Calif.) · 2024Article
- A novel technique for delineating the effect of variation in the learning rate on the neural correlates of reward prediction errors in model-based fMRI.Frontiers in psychology · 2023Article
- A Brief Introduction to Human Behavioral Pharmacology: Methods, Design Considerations and Ethics.Perspectives on behavior science · 2022Article
- Modafinil and its structural analogs as atypical dopamine uptake inhibitors and potential medications for psychostimulant use disorder.Current opinion in pharmacology · 2021Review
- Psychostimulant Use Disorder, an Unmet Therapeutic Goal: Can Modafinil Narrow the Gap?Frontiers in neuroscience · 2021Review
- Pharmacological classification of centrally acting drugs using EEG in freely moving rats: an old tool to identify new atypical dopamine uptake inhibitors.Neuropharmacology · 2019Article
- Role of venlafaxine in relapse to methamphetamine seeking. Potential treatment option for drug dependence.Saudi medical journal · 2019Article
- Participation of Dopamine D1 and D2 Receptors in the Rapid-Onset Behavioral Sensitization to Modafinil.Frontiers in pharmacology · 2019Article
- Oral modafinil facilitates intracranial self-stimulation in rats: comparison with methylphenidate.Behavioural pharmacology · 2017Article
- The unique psychostimulant profile of (±)-modafinil: investigation of behavioral and neurochemical effects in mice.The European journal of neuroscience · 2017Article
- Separate and Combined Effects of Naltrexone and Extended-Release Alprazolam on the Reinforcing, Subject-Rated, and Cardiovascular Effects of Methamphetamine.Journal of clinical psychopharmacology · 2016Article
- Dopaminergic mediation of the discriminative stimulus functions of modafinil in rats.Psychopharmacology · 2015Article
- Effects of modafinil and R-modafinil on brain stimulation reward thresholds: implications for their use in the treatment of psychostimulant dependence.Journal of drug and alcohol research · 2015Article
- Predicting abuse potential of stimulants and other dopaminergic drugs: overview and recommendations.Neuropharmacology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
rationaleThe reinforcing effects of stimulant drugs are modulated by behavioral demands following drug administration.
objectiveThe objective of this study was to assess the reinforcing effects of modafinil, a drug with purportedly low abuse potential, under different behavioral demands using a modified progressive-ratio procedure.
methodsThe reinforcing effects of oral modafinil (0, 100, 200, and 400 mg) were assessed in six healthy adult volunteers under both performance and relaxation conditions. Performance sessions required volunteers to complete simple arithmetic problems for three 50-min blocks. Relaxation sessions required volunteers to sit quietly in a semi-reclined position in a darkened room for three 50-min blocks. Two sampling sessions (one performance and one relaxation session) always preceded two self-administration sessions (one performance and one relaxation session), and the order of performance and relaxation sessions was constant within a dose condition.
resultsModafinil significantly increased break point and number of capsules earned on the modified progressive-ratio procedure as an increasing function of dose under the performance, but not the relaxation, condition. Modafinil produced comparable stimulant-like subjective ratings under both the performance and relaxation conditions.
conclusionThe findings of the present experiment demonstrate that modafinil can function as a reinforcer and that the reinforcing effects of modafinil are influenced by behavioral demands following drug administration, similar to those of other stimulant drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.